Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic CYP3A4 expression and metabolism. However, it remains unclear to what extent the magnitude of PRH-evoked changes in hepatic CYP3A metabolism varies across multiple substrate...

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Bibliographic Details
Main Authors: Muluneh M. Fashe, Taryn A. Miner, John K. Fallon, Amanda P. Schauer, Craig Sykes, Philip C. Smith, Craig R. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
pregnancy
targeted proteomics
CYP3A4
CYP3A5
hepatic metabolism
pregnancy related hormones
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1218703/full

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