Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report
COVID-19 has significantly affected public health, social life, and economies worldwide. The only effective way to combat the pandemic is through vaccines. Although the vaccines have been in use for some time, safety concerns have still been raised. The most typical adverse effects of receiving a CO...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/11/1950 |
| _version_ | 1797463821082689536 |
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| author | Florin Savulescu Cristian Cirlan Madalina Ionela Iordache-Petrescu Mihai Iordache Alexandra Bianca Petrescu Cristian Blajut |
| author_facet | Florin Savulescu Cristian Cirlan Madalina Ionela Iordache-Petrescu Mihai Iordache Alexandra Bianca Petrescu Cristian Blajut |
| author_sort | Florin Savulescu |
| collection | DOAJ |
| description | COVID-19 has significantly affected public health, social life, and economies worldwide. The only effective way to combat the pandemic is through vaccines. Although the vaccines have been in use for some time, safety concerns have still been raised. The most typical adverse effects of receiving a COVID-19 vaccine are localized reactions near the injection site, followed by general physical symptoms such as headaches, fatigue, muscle pain, and fever. Additionally, some people may experience VITT (vaccine-induced immune thrombotic thrombocytopenia), a rare side effect after vaccination. We present the case of a 60-year-old female patient that developed VITT-like symptoms with spleno-portal thrombosis and intestinal ischemia two weeks after the administration of the Ad26.COV2-S vaccine. Surgical treatment consisted of extensive bowel resection with end jejunostomy and feeding ileostomy. Two weeks after the first operation, a duodenal-ileal anastomosis was performed. The patient was discharged five weeks after the onset of the symptoms. Although some rare adverse effects are associated with the SARS-CoV-2 vaccines, the risk of hospitalization from these harmful effects is lower than the risk of hospitalization from COVID-19. Therefore, recognizing VITT is significant for ensuring the early treatment of clots and proper follow-up. |
| first_indexed | 2024-03-09T17:56:09Z |
| format | Article |
| id | doaj.art-5bf6ae1e95e343d2ba9ea49c415463d5 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T17:56:09Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5bf6ae1e95e343d2ba9ea49c415463d52023-11-24T10:17:08ZengMDPI AGVaccines2076-393X2022-11-011011195010.3390/vaccines10111950Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case ReportFlorin Savulescu0Cristian Cirlan1Madalina Ionela Iordache-Petrescu2Mihai Iordache3Alexandra Bianca Petrescu4Cristian Blajut5Department of Medical-Surgical Specialities, “Titu Maiorescu” University of Bucharest, 040441 Bucharest, RomaniaDepartment of Medical-Surgical Specialities, “Titu Maiorescu” University of Bucharest, 040441 Bucharest, RomaniaCentral Military University Emergency Hospital “Dr. Carol Davila”, 010242 Bucharest, RomaniaCentral Military University Emergency Hospital “Dr. Carol Davila”, 010242 Bucharest, RomaniaCentral Military University Emergency Hospital “Dr. Carol Davila”, 010242 Bucharest, RomaniaCentral Military University Emergency Hospital “Dr. Carol Davila”, 010242 Bucharest, RomaniaCOVID-19 has significantly affected public health, social life, and economies worldwide. The only effective way to combat the pandemic is through vaccines. Although the vaccines have been in use for some time, safety concerns have still been raised. The most typical adverse effects of receiving a COVID-19 vaccine are localized reactions near the injection site, followed by general physical symptoms such as headaches, fatigue, muscle pain, and fever. Additionally, some people may experience VITT (vaccine-induced immune thrombotic thrombocytopenia), a rare side effect after vaccination. We present the case of a 60-year-old female patient that developed VITT-like symptoms with spleno-portal thrombosis and intestinal ischemia two weeks after the administration of the Ad26.COV2-S vaccine. Surgical treatment consisted of extensive bowel resection with end jejunostomy and feeding ileostomy. Two weeks after the first operation, a duodenal-ileal anastomosis was performed. The patient was discharged five weeks after the onset of the symptoms. Although some rare adverse effects are associated with the SARS-CoV-2 vaccines, the risk of hospitalization from these harmful effects is lower than the risk of hospitalization from COVID-19. Therefore, recognizing VITT is significant for ensuring the early treatment of clots and proper follow-up.https://www.mdpi.com/2076-393X/10/11/1950portal vein thrombosismesenteric artery thrombosisas26.COV2-S vaccinefeeding ileostomyintestinal ischemia |
| spellingShingle | Florin Savulescu Cristian Cirlan Madalina Ionela Iordache-Petrescu Mihai Iordache Alexandra Bianca Petrescu Cristian Blajut Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report Vaccines portal vein thrombosis mesenteric artery thrombosis as26.COV2-S vaccine feeding ileostomy intestinal ischemia |
| title | Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report |
| title_full | Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report |
| title_fullStr | Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report |
| title_full_unstemmed | Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report |
| title_short | Portal Vein and Mesenteric Artery Thrombosis Following the Administration of an Ad26.COV2-S Vaccine—First Case from Romania: A Case Report |
| title_sort | portal vein and mesenteric artery thrombosis following the administration of an ad26 cov2 s vaccine first case from romania a case report |
| topic | portal vein thrombosis mesenteric artery thrombosis as26.COV2-S vaccine feeding ileostomy intestinal ischemia |
| url | https://www.mdpi.com/2076-393X/10/11/1950 |
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