Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures

Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures

IntroductionInterstitial lung disease (ILD) is a heterogenous group of lung disorders where destruction and incomplete regeneration of the lung parenchyma often results in persistent architectural distortion of the pulmonary scaffold. Continuous mesenchyme-centered, disease-relevant signaling likely...

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Main Authors: Miriam T. Kastlmeier, Erika Gonzalez-Rodriguez, Phoebe Cabanis, Eva M. Guenther, Ann-Christine König, Lianyong Han, Stefanie M. Hauck, Fenja See, Sara Asgharpour, Christina Bukas, Gerald Burgstaller, Marie Piraud, Mareike Lehmann, Rudolf A. Hatz, Jürgen Behr, Tobias Stoeger, Anne Hilgendorff, Carola Voss
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
cytokine
IL11
secretome
interstitial lung disease
organoids
human pluripotent stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128239/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128239/full

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