Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials
Albert Caramoy,1 Ludwig M Heindl2 1Eye Center Wolfsburg-Fallersleben, Wolfsburg, 2Department of Ophthalmology, University of Cologne, Cologne, Germany Aim: The aim was to study the variability of choroidal scleral interface (CSI) thickness in healthy subjects and its relevance for designing future...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-10-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/variability-of-choroidal-and-retinal-thicknesses-in-healthy-eyes-using-peer-reviewed-article-OPTH |
| _version_ | 1818433116320038912 |
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| author | Caramoy A Heindl LM |
| author_facet | Caramoy A Heindl LM |
| author_sort | Caramoy A |
| collection | DOAJ |
| description | Albert Caramoy,1 Ludwig M Heindl2 1Eye Center Wolfsburg-Fallersleben, Wolfsburg, 2Department of Ophthalmology, University of Cologne, Cologne, Germany Aim: The aim was to study the variability of choroidal scleral interface (CSI) thickness in healthy subjects and its relevance for designing future studies. Methods: A total of 123 volunteers were imaged using swept-source optical coherence tomography. Early treatment diabetic retinopathy grid was used. Results: Mean central retinal thickness was 285.85±14.53 µm and 287.18±12.93 µm, and mean central CSI thickness was 273.94±77.77 µm and 271.19±78.85 µm for the right and left eyes, respectively. Mean retinal and CSI thicknesses correlated negatively with age (p=0.023, r=–0.208 and p<0.0001, r=–0.426, respectively) and axial length (p=0.016, r=–0.220 and p<0.0001, r=–0.504, respectively). To detect a CSI change of at least 112 µm, a sample size of 11 or 36 per group is needed for a single- or double-arm study, respectively (α=0.05, power =0.90, no loss to follow-up, assuming standard deviation in future studies as 100 µm). Conclusion: Future clinical studies using CSI as end point are possible with regard to sample size needed. Keywords: swept-source optical coherence tomography, choroidal thickness, retinal thickness, clinical trials |
| first_indexed | 2024-12-14T16:15:59Z |
| format | Article |
| id | doaj.art-5bf9f3cf260c46ab833ed43064306302 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-14T16:15:59Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-5bf9f3cf260c46ab833ed430643063022022-12-21T22:54:54ZengDove Medical PressClinical Ophthalmology1177-54832017-10-01Volume 111835183935150Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trialsCaramoy AHeindl LMAlbert Caramoy,1 Ludwig M Heindl2 1Eye Center Wolfsburg-Fallersleben, Wolfsburg, 2Department of Ophthalmology, University of Cologne, Cologne, Germany Aim: The aim was to study the variability of choroidal scleral interface (CSI) thickness in healthy subjects and its relevance for designing future studies. Methods: A total of 123 volunteers were imaged using swept-source optical coherence tomography. Early treatment diabetic retinopathy grid was used. Results: Mean central retinal thickness was 285.85±14.53 µm and 287.18±12.93 µm, and mean central CSI thickness was 273.94±77.77 µm and 271.19±78.85 µm for the right and left eyes, respectively. Mean retinal and CSI thicknesses correlated negatively with age (p=0.023, r=–0.208 and p<0.0001, r=–0.426, respectively) and axial length (p=0.016, r=–0.220 and p<0.0001, r=–0.504, respectively). To detect a CSI change of at least 112 µm, a sample size of 11 or 36 per group is needed for a single- or double-arm study, respectively (α=0.05, power =0.90, no loss to follow-up, assuming standard deviation in future studies as 100 µm). Conclusion: Future clinical studies using CSI as end point are possible with regard to sample size needed. Keywords: swept-source optical coherence tomography, choroidal thickness, retinal thickness, clinical trialshttps://www.dovepress.com/variability-of-choroidal-and-retinal-thicknesses-in-healthy-eyes-using-peer-reviewed-article-OPTHswept-source optical coherence tomographychoroidal thicknessretinal thicknessclinical trials |
| spellingShingle | Caramoy A Heindl LM Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials Clinical Ophthalmology swept-source optical coherence tomography choroidal thickness retinal thickness clinical trials |
| title | Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials |
| title_full | Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials |
| title_fullStr | Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials |
| title_full_unstemmed | Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials |
| title_short | Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography – implications for designing clinical trials |
| title_sort | variability of choroidal and retinal thicknesses in healthy eyes using swept source optical coherence tomography ndash implications for designing clinical trials |
| topic | swept-source optical coherence tomography choroidal thickness retinal thickness clinical trials |
| url | https://www.dovepress.com/variability-of-choroidal-and-retinal-thicknesses-in-healthy-eyes-using-peer-reviewed-article-OPTH |
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