Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy
AIM: To observe the therapeutic effect of conbercept on diabetic macular edema (DME) complicated with diabetic nephropathy (DN). METHODS: In this retrospective study, 54 patients (54 eyes) that diagnosed as DME from January 2017 to October 2021 were collected. The patients were divided into two grou...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2024/2/20240212.pdf |
| _version_ | 1797348635410694144 |
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| author | Yuan-Zhang Zhu Zhi-Zhi Dou Wen-Ying Wang Qing-Yue Ma Wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang Wen-Juan Luo |
| author_facet | Yuan-Zhang Zhu Zhi-Zhi Dou Wen-Ying Wang Qing-Yue Ma Wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang Wen-Juan Luo |
| author_sort | Yuan-Zhang Zhu |
| collection | DOAJ |
| description | AIM: To observe the therapeutic effect of conbercept on diabetic macular edema (DME) complicated with diabetic nephropathy (DN). METHODS: In this retrospective study, 54 patients (54 eyes) that diagnosed as DME from January 2017 to October 2021 were collected. The patients were divided into two groups: DME patients with DN (25 eyes), and DME patients without DN (29 eyes). General conditions were collected before treatment, laboratory tests include fasting blood glucose, HbA1c, microalbumin/creatinine, serum creatinine. Optical coherence tomography (OCT) was used to check the ellipsoidal zone (EZ) and external limiting membrane (ELM) integrity. Central macular thickness (CMT), best corrected visual acuity (BCVA), and retinal hyperreflective foci (HF) as well as numbers of injections were recorded. RESULTS: There were significant differences between fasting blood glucose, HbA1c, serum creatinine, urinary microalbumin/creatinine, and estimated glomerular filtration rate (eGFR) between the two groups (all P<0.05). EZ and ELM continuity in the DME+DN group was worse than that in the DME group (P<0.05). BCVA (logMAR) in the DME group was significantly better than that in the DME+DN group at the same time points during treatment (all P<0.05). CMT and HF values were significantly higher in the DME+DN group than that in the DME group at the all time points (all P<0.05) and significantly decreased in both groups with time during treatment. At 6mo after treatment, the mean number of injections in the DME+DN and DME group was 4.84±0.94 and 3.79±0.86, respectively. CONCLUSION: Conbercept has a significant effect in short-term treatment of DME patients with or without DN, and can significantly ameliorate BCVA, CMT and the number of HF, treatment efficacy of DME patients without DN is better than that of DME patients with DN. |
| first_indexed | 2024-03-08T12:08:37Z |
| format | Article |
| id | doaj.art-5bfba2690e9e4312af273dd6d8eb7e86 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-08T12:08:37Z |
| publishDate | 2024-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-5bfba2690e9e4312af273dd6d8eb7e862024-01-23T03:42:33ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982024-02-0117230431010.18240/ijo.2024.02.1220240212Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathyYuan-Zhang Zhu0Zhi-Zhi Dou1Wen-Ying Wang2Qing-Yue Ma3Wen-Dan Yi4Ning-Ning Yao5Yi-Chong Liu6Xiao-Di Gao7Qian Zhang8Wen-Juan Luo9Wen-Juan Luo. Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China. luowenjuan@qdu.edu.cnDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaAIM: To observe the therapeutic effect of conbercept on diabetic macular edema (DME) complicated with diabetic nephropathy (DN). METHODS: In this retrospective study, 54 patients (54 eyes) that diagnosed as DME from January 2017 to October 2021 were collected. The patients were divided into two groups: DME patients with DN (25 eyes), and DME patients without DN (29 eyes). General conditions were collected before treatment, laboratory tests include fasting blood glucose, HbA1c, microalbumin/creatinine, serum creatinine. Optical coherence tomography (OCT) was used to check the ellipsoidal zone (EZ) and external limiting membrane (ELM) integrity. Central macular thickness (CMT), best corrected visual acuity (BCVA), and retinal hyperreflective foci (HF) as well as numbers of injections were recorded. RESULTS: There were significant differences between fasting blood glucose, HbA1c, serum creatinine, urinary microalbumin/creatinine, and estimated glomerular filtration rate (eGFR) between the two groups (all P<0.05). EZ and ELM continuity in the DME+DN group was worse than that in the DME group (P<0.05). BCVA (logMAR) in the DME group was significantly better than that in the DME+DN group at the same time points during treatment (all P<0.05). CMT and HF values were significantly higher in the DME+DN group than that in the DME group at the all time points (all P<0.05) and significantly decreased in both groups with time during treatment. At 6mo after treatment, the mean number of injections in the DME+DN and DME group was 4.84±0.94 and 3.79±0.86, respectively. CONCLUSION: Conbercept has a significant effect in short-term treatment of DME patients with or without DN, and can significantly ameliorate BCVA, CMT and the number of HF, treatment efficacy of DME patients without DN is better than that of DME patients with DN.http://ies.ijo.cn/en_publish/2024/2/20240212.pdfconberceptdiabetic nephropathydiabetic macular edemaoptical coherence tomography |
| spellingShingle | Yuan-Zhang Zhu Zhi-Zhi Dou Wen-Ying Wang Qing-Yue Ma Wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang Wen-Juan Luo Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy International Journal of Ophthalmology conbercept diabetic nephropathy diabetic macular edema optical coherence tomography |
| title | Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| title_full | Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| title_fullStr | Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| title_full_unstemmed | Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| title_short | Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| title_sort | intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy |
| topic | conbercept diabetic nephropathy diabetic macular edema optical coherence tomography |
| url | http://ies.ijo.cn/en_publish/2024/2/20240212.pdf |
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