Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis
Evidence-based guidelines recommend cascade genetic testing of blood relatives of known Hereditary Breast and Ovarian Cancer (HBOC) or Lynch Syndrome (LS) cases, to inform individualized cancer screening and prevention plans. The study identified interventions designed to facilitate family communica...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/4/925 |
| _version_ | 1797395569395630080 |
|---|---|
| author | Vasiliki Baroutsou Meghan L. Underhill-Blazey Christian Appenzeller-Herzog Maria C. Katapodi |
| author_facet | Vasiliki Baroutsou Meghan L. Underhill-Blazey Christian Appenzeller-Herzog Maria C. Katapodi |
| author_sort | Vasiliki Baroutsou |
| collection | DOAJ |
| description | Evidence-based guidelines recommend cascade genetic testing of blood relatives of known Hereditary Breast and Ovarian Cancer (HBOC) or Lynch Syndrome (LS) cases, to inform individualized cancer screening and prevention plans. The study identified interventions designed to facilitate family communication of genetic testing results and/or cancer predisposition cascade genetic testing for HBOC and LS. We conducted a systematic review and meta-analysis of randomized trials that assessed intervention efficacy for these two outcomes. Additional outcomes were also recorded and synthesized when possible. Fourteen articles met the inclusion criteria and were included in the narrative synthesis and 13 in the meta-analysis. Lack of participant blinding was the most common risk of bias. Interventions targeted HBOC (<i>n =</i> 5); both HBOC and LS (<i>n =</i> 4); LS (<i>n =</i> 3); or ovarian cancer (<i>n =</i> 2). All protocols (<i>n =</i> 14) included a psychoeducational and/or counseling component. Additional components were decision aids (<i>n =</i> 4), building communication skills (<i>n =</i> 4), or motivational interviewing (<i>n =</i> 1). The overall effect size for family communication was small (<i>g =</i> 0.085) and not significant (<i>p =</i> 0.344), while for cascade testing, it was small (<i>g =</i> 0.169) but significant (<i>p =</i> 0.014). Interventions show promise for improving cancer predisposition cascade genetic testing for HBOC and LS. Future studies should employ family-based approaches and include racially diverse samples. |
| first_indexed | 2024-03-09T00:37:25Z |
| format | Article |
| id | doaj.art-5bfbc07dcc3b4be8b7f8f0f5e20f2a5b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T00:37:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5bfbc07dcc3b4be8b7f8f0f5e20f2a5b2023-12-11T18:03:24ZengMDPI AGCancers2072-66942021-02-0113492510.3390/cancers13040925Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-AnalysisVasiliki Baroutsou0Meghan L. Underhill-Blazey1Christian Appenzeller-Herzog2Maria C. Katapodi3Department of Clinical Research, Faculty of Medicine, University of Basel, 4055 Basel, SwitzerlandSchool of Nursing, Wilmot Cancer Institute Hereditary Cancer Program, University of Rochester, Rochester, NY 14642, USAUniversity Medical Library, University of Basel, 4051 Basel, SwitzerlandDepartment of Clinical Research, Faculty of Medicine, University of Basel, 4055 Basel, SwitzerlandEvidence-based guidelines recommend cascade genetic testing of blood relatives of known Hereditary Breast and Ovarian Cancer (HBOC) or Lynch Syndrome (LS) cases, to inform individualized cancer screening and prevention plans. The study identified interventions designed to facilitate family communication of genetic testing results and/or cancer predisposition cascade genetic testing for HBOC and LS. We conducted a systematic review and meta-analysis of randomized trials that assessed intervention efficacy for these two outcomes. Additional outcomes were also recorded and synthesized when possible. Fourteen articles met the inclusion criteria and were included in the narrative synthesis and 13 in the meta-analysis. Lack of participant blinding was the most common risk of bias. Interventions targeted HBOC (<i>n =</i> 5); both HBOC and LS (<i>n =</i> 4); LS (<i>n =</i> 3); or ovarian cancer (<i>n =</i> 2). All protocols (<i>n =</i> 14) included a psychoeducational and/or counseling component. Additional components were decision aids (<i>n =</i> 4), building communication skills (<i>n =</i> 4), or motivational interviewing (<i>n =</i> 1). The overall effect size for family communication was small (<i>g =</i> 0.085) and not significant (<i>p =</i> 0.344), while for cascade testing, it was small (<i>g =</i> 0.169) but significant (<i>p =</i> 0.014). Interventions show promise for improving cancer predisposition cascade genetic testing for HBOC and LS. Future studies should employ family-based approaches and include racially diverse samples.https://www.mdpi.com/2072-6694/13/4/925Tier-1 genetic conditionsintervention efficacyrandomized controlled trialspsychoeducational interventions |
| spellingShingle | Vasiliki Baroutsou Meghan L. Underhill-Blazey Christian Appenzeller-Herzog Maria C. Katapodi Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis Cancers Tier-1 genetic conditions intervention efficacy randomized controlled trials psychoeducational interventions |
| title | Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis |
| title_full | Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis |
| title_fullStr | Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis |
| title_short | Interventions Facilitating Family Communication of Genetic Testing Results and Cascade Screening in Hereditary Breast/Ovarian Cancer or Lynch Syndrome: A Systematic Review and Meta-Analysis |
| title_sort | interventions facilitating family communication of genetic testing results and cascade screening in hereditary breast ovarian cancer or lynch syndrome a systematic review and meta analysis |
| topic | Tier-1 genetic conditions intervention efficacy randomized controlled trials psychoeducational interventions |
| url | https://www.mdpi.com/2072-6694/13/4/925 |
| work_keys_str_mv | AT vasilikibaroutsou interventionsfacilitatingfamilycommunicationofgenetictestingresultsandcascadescreeninginhereditarybreastovariancancerorlynchsyndromeasystematicreviewandmetaanalysis AT meghanlunderhillblazey interventionsfacilitatingfamilycommunicationofgenetictestingresultsandcascadescreeninginhereditarybreastovariancancerorlynchsyndromeasystematicreviewandmetaanalysis AT christianappenzellerherzog interventionsfacilitatingfamilycommunicationofgenetictestingresultsandcascadescreeninginhereditarybreastovariancancerorlynchsyndromeasystematicreviewandmetaanalysis AT mariackatapodi interventionsfacilitatingfamilycommunicationofgenetictestingresultsandcascadescreeninginhereditarybreastovariancancerorlynchsyndromeasystematicreviewandmetaanalysis |