Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity
BACKGROUND: Obesity has a central role in the metabolic syndrome, which raises the risk for atherosclerotic cardiovascular disease (ASVCD). Apo B-48 and Apo B-100 are the necessary structural proteins required for the assembly and secretion of chylomicron and VLDL which have role in atherogenesis. T...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Secretariat of The Indonesian Biomedical Journal
2010-08-01
|
| Series: | Indonesian Biomedical Journal |
| Online Access: | http://inabj.org/index.php/ibj/article/view/120 |
| _version_ | 1828390481645535232 |
|---|---|
| author | Maria Diah Fibriani Andi Wijaya Burhanuddin Bahar |
| author_facet | Maria Diah Fibriani Andi Wijaya Burhanuddin Bahar |
| author_sort | Maria Diah Fibriani |
| collection | DOAJ |
| description | BACKGROUND: Obesity has a central role in the metabolic syndrome, which raises the risk for atherosclerotic cardiovascular disease (ASVCD). Apo B-48 and Apo B-100 are the necessary structural proteins required for the assembly and secretion of chylomicron and VLDL which have role in atherogenesis. The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Oxidation of LDL is a hallmark of atherosclerosis development. The aim of this study was to asses the association between Apo B-48 and Apo B-100 with Oxidized-LDL as marker of atherosclerosis risk in central obesity. We hope that the result of this study can help to make a new strategy for the prevention and treatment of vascular disease. RESULTS: There were 68 patients aged 39.6±7.3 years, Apo B-48 concentration was 7.47±5.36 μg/mL, Apo B-100 was 117.26±25.74 mg/dL, and ox-LDL was 137.05±18.88 U/L. This study showed a significant correlation between Apo B-100 and ox-LDL (r=0.608, p<0.05) and correlation between Apo B-48 and ox-LDL (r= 0.171, p<0.05). The levels of Apo B-100 were significantly different between obese with Mets and obese without Mets individuals (p<0.05). CONCLUSIONS: This study suggested that Apo B-100 concentration increase in obese in Mets as compared with obese without Mets. Apo B-48 and Apo B-100 were correlated with Oxidized LDL, but correlation between Apo B-100 and ox-LDL more significant that Apo B-48and ox-LDL. KEYWORDS: obesity, atherogenesis, Apo B-48, Apo B-100, ox-LDL. |
| first_indexed | 2024-12-10T06:45:08Z |
| format | Article |
| id | doaj.art-5bfc22fa74c44b108cbc1a744dd2626e |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-12-10T06:45:08Z |
| publishDate | 2010-08-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-5bfc22fa74c44b108cbc1a744dd2626e2022-12-22T01:58:41ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792010-08-012253810.18585/inabj.v2i2.120112Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central ObesityMaria Diah Fibriani0Andi Wijaya1Burhanuddin Bahar2Post Graduate Program in Clinical Biochemistry, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarPost Graduate Program in Clinical Biochemistry, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarFaculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarBACKGROUND: Obesity has a central role in the metabolic syndrome, which raises the risk for atherosclerotic cardiovascular disease (ASVCD). Apo B-48 and Apo B-100 are the necessary structural proteins required for the assembly and secretion of chylomicron and VLDL which have role in atherogenesis. The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Oxidation of LDL is a hallmark of atherosclerosis development. The aim of this study was to asses the association between Apo B-48 and Apo B-100 with Oxidized-LDL as marker of atherosclerosis risk in central obesity. We hope that the result of this study can help to make a new strategy for the prevention and treatment of vascular disease. RESULTS: There were 68 patients aged 39.6±7.3 years, Apo B-48 concentration was 7.47±5.36 μg/mL, Apo B-100 was 117.26±25.74 mg/dL, and ox-LDL was 137.05±18.88 U/L. This study showed a significant correlation between Apo B-100 and ox-LDL (r=0.608, p<0.05) and correlation between Apo B-48 and ox-LDL (r= 0.171, p<0.05). The levels of Apo B-100 were significantly different between obese with Mets and obese without Mets individuals (p<0.05). CONCLUSIONS: This study suggested that Apo B-100 concentration increase in obese in Mets as compared with obese without Mets. Apo B-48 and Apo B-100 were correlated with Oxidized LDL, but correlation between Apo B-100 and ox-LDL more significant that Apo B-48and ox-LDL. KEYWORDS: obesity, atherogenesis, Apo B-48, Apo B-100, ox-LDL.http://inabj.org/index.php/ibj/article/view/120 |
| spellingShingle | Maria Diah Fibriani Andi Wijaya Burhanuddin Bahar Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity Indonesian Biomedical Journal |
| title | Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity |
| title_full | Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity |
| title_fullStr | Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity |
| title_full_unstemmed | Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity |
| title_short | Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity |
| title_sort | correlation of apo b 48 and apo b 100 with oxidized ldl in men with central obesity |
| url | http://inabj.org/index.php/ibj/article/view/120 |
| work_keys_str_mv | AT mariadiahfibriani correlationofapob48andapob100withoxidizedldlinmenwithcentralobesity AT andiwijaya correlationofapob48andapob100withoxidizedldlinmenwithcentralobesity AT burhanuddinbahar correlationofapob48andapob100withoxidizedldlinmenwithcentralobesity |