Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells
Gold nanostructure can be manufactured in many forms, such as spherical by using simple chemical method. X-ray powder diffraction (XRD) pattern of gold nanoparticles (AuNPs) was derived from a 400-μL trisodium citrate solution. The diffraction peaks corresponding to the diffraction planes of (111),...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-03-01
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| Series: | Nano Biomedicine and Engineering |
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| Online Access: | https://www.sciopen.com/article/10.26599/NBE.2023.9290015 |
| _version_ | 1797673306494599168 |
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| author | Majid S. Khalaf Marwa Abdul Muhsien Hassan Asmaa Hadi Mohammed |
| author_facet | Majid S. Khalaf Marwa Abdul Muhsien Hassan Asmaa Hadi Mohammed |
| author_sort | Majid S. Khalaf |
| collection | DOAJ |
| description | Gold nanostructure can be manufactured in many forms, such as spherical by using simple chemical method. X-ray powder diffraction (XRD) pattern of gold nanoparticles (AuNPs) was derived from a 400-μL trisodium citrate solution. The diffraction peaks corresponding to the diffraction planes of (111), (200), and (220) were all indexed to the gold with a face-centered cubic structure. The lattice constant calculated from the XRD pattern is 4.078 Å, which matches the conventional cubic gold metal diffraction pattern well (Pattern card number (04-784)). The results of scanning electronic microscope show that the biological nanoparticles of gold have asymmetric shapes and different sizes grouped as a circular particle. It was observed that the fashioning of AuNPs increased with increase in the concentration of [6]-gingerol waste extracts. The viability of FTC-133 cells treated for 48 h with various concentrations of [6]-gingerol extract coated with AuNPs (12.5–400 g/mL) was used to determine the cytotoxicity. A dose-dependent reduction in FTC-133 cell viability caused by [6]-gingerol extract capped with Au NPs was substantial (P < 0.05), reaching 75% cell mortality at 400 g/mL; the IC50 was 90.5%. |
| first_indexed | 2024-03-11T21:43:35Z |
| format | Article |
| id | doaj.art-5bfdbb973dc542df9eedca93d3c3f698 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:35Z |
| publishDate | 2023-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-5bfdbb973dc542df9eedca93d3c3f6982023-09-26T11:05:57ZengTsinghua University PressNano Biomedicine and Engineering2150-55782023-03-01151364110.26599/NBE.2023.9290015Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma CellsMajid S. Khalaf0Marwa Abdul Muhsien Hassan1Asmaa Hadi Mohammed2Minisitry of Science and Technology, Baghdad, IraqDepartment of Physics, College of Science, Mustansiriyah University, Baghdad, IraqDepartment of Physics, College of Science, Al-Nahrain University, Baghdad, IraqGold nanostructure can be manufactured in many forms, such as spherical by using simple chemical method. X-ray powder diffraction (XRD) pattern of gold nanoparticles (AuNPs) was derived from a 400-μL trisodium citrate solution. The diffraction peaks corresponding to the diffraction planes of (111), (200), and (220) were all indexed to the gold with a face-centered cubic structure. The lattice constant calculated from the XRD pattern is 4.078 Å, which matches the conventional cubic gold metal diffraction pattern well (Pattern card number (04-784)). The results of scanning electronic microscope show that the biological nanoparticles of gold have asymmetric shapes and different sizes grouped as a circular particle. It was observed that the fashioning of AuNPs increased with increase in the concentration of [6]-gingerol waste extracts. The viability of FTC-133 cells treated for 48 h with various concentrations of [6]-gingerol extract coated with AuNPs (12.5–400 g/mL) was used to determine the cytotoxicity. A dose-dependent reduction in FTC-133 cell viability caused by [6]-gingerol extract capped with Au NPs was substantial (P < 0.05), reaching 75% cell mortality at 400 g/mL; the IC50 was 90.5%.https://www.sciopen.com/article/10.26599/NBE.2023.9290015colloidal gold3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) cytotoxicity[6]-gingerol2,2-diphenyl-1-picrylhydrazyl (dpph) |
| spellingShingle | Majid S. Khalaf Marwa Abdul Muhsien Hassan Asmaa Hadi Mohammed Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells Nano Biomedicine and Engineering colloidal gold 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) cytotoxicity [6]-gingerol 2,2-diphenyl-1-picrylhydrazyl (dpph) |
| title | Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells |
| title_full | Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells |
| title_fullStr | Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells |
| title_full_unstemmed | Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells |
| title_short | Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells |
| title_sort | exploring the role of phytochemicals effect of 6 gingerol combined with colloidal gold nanoparticles on thyroid carcinoma cells |
| topic | colloidal gold 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (mtt) cytotoxicity [6]-gingerol 2,2-diphenyl-1-picrylhydrazyl (dpph) |
| url | https://www.sciopen.com/article/10.26599/NBE.2023.9290015 |
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