Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use
This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylam...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Polymer Testing |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941822002811 |
| _version_ | 1811226142483415040 |
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| author | Kateřina Škrlová Zuzana Rybková Tereza Stachurová Jakub Zagora Kateřina Malachová Dagmar Měřinská Roman Gabor Miroslav Havlíček Alexandra Muñoz-Bonilla Marta Fernández-García Daniela Plachá |
| author_facet | Kateřina Škrlová Zuzana Rybková Tereza Stachurová Jakub Zagora Kateřina Malachová Dagmar Měřinská Roman Gabor Miroslav Havlíček Alexandra Muñoz-Bonilla Marta Fernández-García Daniela Plachá |
| author_sort | Kateřina Škrlová |
| collection | DOAJ |
| description | This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0–6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation. |
| first_indexed | 2024-04-12T09:20:22Z |
| format | Article |
| id | doaj.art-5bfddbe01fac40fb9915d7fcf16268aa |
| institution | Directory Open Access Journal |
| issn | 0142-9418 |
| language | English |
| last_indexed | 2024-04-12T09:20:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj.art-5bfddbe01fac40fb9915d7fcf16268aa2022-12-22T03:38:41ZengElsevierPolymer Testing0142-94182022-12-01116107760Long-term antimicrobial effect of polylactide-based composites suitable for biomedical useKateřina Škrlová0Zuzana Rybková1Tereza Stachurová2Jakub Zagora3Kateřina Malachová4Dagmar Měřinská5Roman Gabor6Miroslav Havlíček7Alexandra Muñoz-Bonilla8Marta Fernández-García9Daniela Plachá10Nanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic; Center of Advanced Innovation Technologies, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech RepublicDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00, Ostrava, Czech RepublicDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00, Ostrava, Czech RepublicNanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic; Center of Advanced Innovation Technologies, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech RepublicDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00, Ostrava, Czech RepublicFaculty of Technology, Tomas Bata University in Zlín, Vavrečkova 275, 760 01, Zlín, Czech RepublicNanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech RepublicMedin,a.s., Nové Město na Moravě, Czech RepublicInstitute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, 28006, Madrid, SpainInstitute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, 28006, Madrid, SpainNanotechnology Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic; ENET Centre, CEET, VSB – Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic; Corresponding author. Nanotechnology Centre, CEET, VSB - Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic.This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0–6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation.http://www.sciencedirect.com/science/article/pii/S0142941822002811PolylactidePolymer compositesAntimicrobial effectSilverHDTMAHDP |
| spellingShingle | Kateřina Škrlová Zuzana Rybková Tereza Stachurová Jakub Zagora Kateřina Malachová Dagmar Měřinská Roman Gabor Miroslav Havlíček Alexandra Muñoz-Bonilla Marta Fernández-García Daniela Plachá Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use Polymer Testing Polylactide Polymer composites Antimicrobial effect Silver HDTMA HDP |
| title | Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use |
| title_full | Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use |
| title_fullStr | Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use |
| title_full_unstemmed | Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use |
| title_short | Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use |
| title_sort | long term antimicrobial effect of polylactide based composites suitable for biomedical use |
| topic | Polylactide Polymer composites Antimicrobial effect Silver HDTMA HDP |
| url | http://www.sciencedirect.com/science/article/pii/S0142941822002811 |
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