The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in Heart Tissue of Diabetic Rats
Objective: It was reported exercise and herbal medicine can possess synergistic effects to control of diabetes complications. The purpose of the present study was investigation of the effects of high-intensity interval training (HIIT) and taking curcumin supplement on activity levels of GPX and MDA...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2016-12-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-323-en.html |
| _version_ | 1818664726242000896 |
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| author | Abbas Fattahi Bafghi Hasan Matin Homaei Moahmmad-Ali Azarbayjani |
| author_facet | Abbas Fattahi Bafghi Hasan Matin Homaei Moahmmad-Ali Azarbayjani |
| author_sort | Abbas Fattahi Bafghi |
| collection | DOAJ |
| description | Objective: It was reported exercise and herbal medicine can possess synergistic effects to control of diabetes complications. The purpose of the present study was investigation of the effects of high-intensity interval training (HIIT) and taking curcumin supplement on activity levels of GPX and MDA of heart tissue in diabetic rats.
Materials and Methods: Thirty-two male Wistar rats were randomly divided to four groups of curcumin, training-placebo, training-curcumin, and control. The subjects had being trained to perform HIIT on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin had being nourished to the animals of the curcumin groups, by using the gavage technique, during a period of eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hours after the intervention. Then, heart tissues were separated from bodies of the rats to examine changes in GPX and MDA enzymes.
Results: Activity levels of GPX enzyme of the three groups of curcumin, training-placebo, and training-curcumin increased significantly than correspondent levels of the control group. Activity levels of MDA enzyme of the three groups of curcumin, training-placebo, and training-curcumin decreased significantly than correspondent levels of the control group. Though, no significant difference was observed between those first three groups (P-value≤0.05).
Discussion: The findings indicated that either HIIT or taking curcumin supplement or combination of both could solely contribute significant enhancement to activity levels of antioxidant enzymes and decreasing of Oxidative enzymes within heart tissues of diabetic mice. Although, those two interventions would not strengthen the influences of each other in decrease of MDA but they would strengthen the influences of each other in increasing of GPX. |
| first_indexed | 2024-12-17T05:37:19Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-12-17T05:37:19Z |
| publishDate | 2016-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-5c009674423b4f32868632bbbc31cab62022-12-21T22:01:34ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502016-12-0184196202The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in Heart Tissue of Diabetic RatsAbbas Fattahi Bafghi0Hasan Matin Homaei1Moahmmad-Ali Azarbayjani2 PhD Student of Exercise Physiology, Islamic Azad University ,Central Tehran Branch, Tehran, Iran. Assistant Professor, Islamic Azad University ,Central Tehran Branch, Tehran, Iran. Professor, Islamic Azad University ,Central Tehran Branch, Tehran, Iran. Objective: It was reported exercise and herbal medicine can possess synergistic effects to control of diabetes complications. The purpose of the present study was investigation of the effects of high-intensity interval training (HIIT) and taking curcumin supplement on activity levels of GPX and MDA of heart tissue in diabetic rats. Materials and Methods: Thirty-two male Wistar rats were randomly divided to four groups of curcumin, training-placebo, training-curcumin, and control. The subjects had being trained to perform HIIT on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin had being nourished to the animals of the curcumin groups, by using the gavage technique, during a period of eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hours after the intervention. Then, heart tissues were separated from bodies of the rats to examine changes in GPX and MDA enzymes. Results: Activity levels of GPX enzyme of the three groups of curcumin, training-placebo, and training-curcumin increased significantly than correspondent levels of the control group. Activity levels of MDA enzyme of the three groups of curcumin, training-placebo, and training-curcumin decreased significantly than correspondent levels of the control group. Though, no significant difference was observed between those first three groups (P-value≤0.05). Discussion: The findings indicated that either HIIT or taking curcumin supplement or combination of both could solely contribute significant enhancement to activity levels of antioxidant enzymes and decreasing of Oxidative enzymes within heart tissues of diabetic mice. Although, those two interventions would not strengthen the influences of each other in decrease of MDA but they would strengthen the influences of each other in increasing of GPX.http://ijdo.ssu.ac.ir/article-1-323-en.htmlCurcuminHigh-intensity interval trainingDiabetic male rats |
| spellingShingle | Abbas Fattahi Bafghi Hasan Matin Homaei Moahmmad-Ali Azarbayjani The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in Heart Tissue of Diabetic Rats Iranian Journal of Diabetes and Obesity Curcumin High-intensity interval training Diabetic male rats |
| title | The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in
Heart Tissue of Diabetic Rats |
| title_full | The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in
Heart Tissue of Diabetic Rats |
| title_fullStr | The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in
Heart Tissue of Diabetic Rats |
| title_full_unstemmed | The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in
Heart Tissue of Diabetic Rats |
| title_short | The Effects of High-Intensity Interval Training and Curcumin Supplement on Concentrations of Antioxidant Enzyme and Oxidative Stress in
Heart Tissue of Diabetic Rats |
| title_sort | effects of high intensity interval training and curcumin supplement on concentrations of antioxidant enzyme and oxidative stress in heart tissue of diabetic rats |
| topic | Curcumin High-intensity interval training Diabetic male rats |
| url | http://ijdo.ssu.ac.ir/article-1-323-en.html |
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