Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI
Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer’s disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-04-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00106/full |
| _version_ | 1811283743580618752 |
|---|---|
| author | Shankar Tumati Shankar Tumati Esther M. Opmeer Jan-Bernard C. Marsman Sander Martens Fransje E. Reesink Peter P. De Deyn Peter P. De Deyn André Aleman André Aleman |
| author_facet | Shankar Tumati Shankar Tumati Esther M. Opmeer Jan-Bernard C. Marsman Sander Martens Fransje E. Reesink Peter P. De Deyn Peter P. De Deyn André Aleman André Aleman |
| author_sort | Shankar Tumati |
| collection | DOAJ |
| description | Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer’s disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (1H-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1H-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporo-parietal cortex (TPC). Apathy was measured with the Apathy Evaluation Scale (AES). Spearman partial correlations between metabolite concentrations in each region and severity of apathy were determined. Additionally, analyses of covariance (ANCOVA) were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed apathy. The degree of apathy was found to be negatively correlated with choline and myo-inositol (mI) in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA)/mI ratio was reduced in aMCI without clinical apathy but not in aMCI with clinical apathy. In the DACC, glutamate and glutamine (Glx) levels tended to be higher in the aMCI with apathy group compared to controls and reduced in association with depression scores. In conclusion, apathy in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort, apathy symptoms may be suggestive of neural changes that are distinct from aMCI without apathy. |
| first_indexed | 2024-04-13T02:18:01Z |
| format | Article |
| id | doaj.art-5c02a1a0ac3a42b68ba4c6e6a9426f5d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T02:18:01Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5c02a1a0ac3a42b68ba4c6e6a9426f5d2022-12-22T03:07:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-04-011010.3389/fnagi.2018.00106330670Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCIShankar Tumati0Shankar Tumati1Esther M. Opmeer2Jan-Bernard C. Marsman3Sander Martens4Fransje E. Reesink5Peter P. De Deyn6Peter P. De Deyn7André Aleman8André Aleman9Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsMind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa; Royal Ottawa Mental Health Centre, Ottawa, ON, CanadaDepartment of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsLaboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumDepartment of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Psychology, University of Groningen, Groningen, NetherlandsApathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer’s disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (1H-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent 1H-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporo-parietal cortex (TPC). Apathy was measured with the Apathy Evaluation Scale (AES). Spearman partial correlations between metabolite concentrations in each region and severity of apathy were determined. Additionally, analyses of covariance (ANCOVA) were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed apathy. The degree of apathy was found to be negatively correlated with choline and myo-inositol (mI) in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA)/mI ratio was reduced in aMCI without clinical apathy but not in aMCI with clinical apathy. In the DACC, glutamate and glutamine (Glx) levels tended to be higher in the aMCI with apathy group compared to controls and reduced in association with depression scores. In conclusion, apathy in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort, apathy symptoms may be suggestive of neural changes that are distinct from aMCI without apathy.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00106/fullapathyamnestic MCItemporo-parietal cortexgoal-directed behaviorcholinemyo-inositol |
| spellingShingle | Shankar Tumati Shankar Tumati Esther M. Opmeer Jan-Bernard C. Marsman Sander Martens Fransje E. Reesink Peter P. De Deyn Peter P. De Deyn André Aleman André Aleman Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI Frontiers in Aging Neuroscience apathy amnestic MCI temporo-parietal cortex goal-directed behavior choline myo-inositol |
| title | Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI |
| title_full | Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI |
| title_fullStr | Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI |
| title_full_unstemmed | Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI |
| title_short | Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI |
| title_sort | lower choline and myo inositol in temporo parietal cortex is associated with apathy in amnestic mci |
| topic | apathy amnestic MCI temporo-parietal cortex goal-directed behavior choline myo-inositol |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00106/full |
| work_keys_str_mv | AT shankartumati lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT shankartumati lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT esthermopmeer lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT janbernardcmarsman lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT sandermartens lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT fransjeereesink lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT peterpdedeyn lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT peterpdedeyn lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT andrealeman lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci AT andrealeman lowercholineandmyoinositolintemporoparietalcortexisassociatedwithapathyinamnesticmci |