Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD
Background Low attenuation area ratio (LAA%) and pectoral major parameters are in elderly patients with COPD related to pulmonary ventilation function, but there are few studies at home and abroad. Objective To analyze the correlation of LAA% and pectoral major parameters with impaired pulmonary ven...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-09-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220263.pdf |
| _version_ | 1797217098666082304 |
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| author | Yalin WANG, Jing ZHANG, Muyun ZHU |
| author_facet | Yalin WANG, Jing ZHANG, Muyun ZHU |
| author_sort | Yalin WANG, Jing ZHANG, Muyun ZHU |
| collection | DOAJ |
| description | Background Low attenuation area ratio (LAA%) and pectoral major parameters are in elderly patients with COPD related to pulmonary ventilation function, but there are few studies at home and abroad. Objective To analyze the correlation of LAA% and pectoral major parameters with impaired pulmonary ventilation function in elderly patients with COPD, and to explore the predictive value of LAA% and PMcsa in the severity of airflow restriction, in order to provide clinical basis for the early detection and diagnosis of COPD. Methods A total of 270 elderly patients with stable COPD who underwent chest CT and lung function examination in North Jiangsu People's Hospital affiliated to Yangzhou University from December 2019 to June 2021 were selected and divided into GOLDⅠgroup (FEVl%pred≥80%, n=47) , GOLD Ⅱgroup (50%≤FEVl%pred<80%, n=88) , GOLD Ⅲ group (30%≤FEVl%pred<50%, n=84) and GOLD Ⅳ group (FEVl%pred<30%, n=51) according to GOLD classification with their general information and CT quantitative indexes recorded. Pearson correlation analysis and multiple linear regression analysis were used to explore the relationship between LAA%, pectoralis major areas (PMcsa) and lung function. The receiver operating characteristic curve (ROC curve) was used to evaluate the predictive value of LAA% and PMcsa for FEV1%pred<50% and FEV1%pred<80%. Results BMI and PMD in GOLDⅠgroup were higher than those in GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) , and the BMI in GOLD Ⅱgroup and GOLD Ⅲ group was higher than that in GOLD Ⅳ group (P<0.05) . PMcsa, PMI, FEV1%pred, FEV1 and FVC in GOLD Ⅰgroup were higher than those in GOLD Ⅱ group, GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . PMcsa, PMI, FEV1%pred, FEV1 and FVC in GOLD Ⅱ group were higher than those in GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . PMcsa, PMI , FEV1%pred, FEV1 and FVC in GOLD Ⅲ group were higher than those in GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅰ group were lower than those in GOLD Ⅱ group, GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅱ group were lower than those in GOLDⅢ group and GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅲ group were lower than those in GOLD Ⅳ group (P<0.05) . FEV1%pred, FEV1 and FVC were positively correlated with PMcsa, PMI and PMD (P<0.05) . Both FEV1%pred and FEV1 were negatively correlated with low attenuation area ratio (right LAA%, left LAA%, total LAA%) (P<0.05) . Multiple linear regression analysis show that gender, total LAA% and PMcsa were independent influencing factors of FEV1%pred. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<50% in male patients were 0.832, 0.827, 0.834, 0.809, respectively. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<50% in female patientswere 0.844, 0.801, 0.845, 0.839, respectively. The area under ROC curve of right lung LAA%, Left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<80% in male patients were 0.830, 0.815, 0.831, 0.844, respectively. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<80% in female patients were 0.805, 0.817, 0.807, 0.846, respectively. Conclusion The low attenuation area ratio and PMcsa can assess the severity of airflow restriction in elderly patients with COPD, and can be used as an important tool for early screening and severity assessment of COPD. |
| first_indexed | 2024-04-24T11:56:27Z |
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| id | doaj.art-5c03d2f00f4d4627acedd7cb5a2d867d |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:56:27Z |
| publishDate | 2022-09-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-5c03d2f00f4d4627acedd7cb5a2d867d2024-04-09T04:10:36ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-09-0125273358336410.12114/j.issn.1007-9572.2022.0263Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPDYalin WANG, Jing ZHANG, Muyun ZHU0Department of Geriatric Medicine, North Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, ChinaBackground Low attenuation area ratio (LAA%) and pectoral major parameters are in elderly patients with COPD related to pulmonary ventilation function, but there are few studies at home and abroad. Objective To analyze the correlation of LAA% and pectoral major parameters with impaired pulmonary ventilation function in elderly patients with COPD, and to explore the predictive value of LAA% and PMcsa in the severity of airflow restriction, in order to provide clinical basis for the early detection and diagnosis of COPD. Methods A total of 270 elderly patients with stable COPD who underwent chest CT and lung function examination in North Jiangsu People's Hospital affiliated to Yangzhou University from December 2019 to June 2021 were selected and divided into GOLDⅠgroup (FEVl%pred≥80%, n=47) , GOLD Ⅱgroup (50%≤FEVl%pred<80%, n=88) , GOLD Ⅲ group (30%≤FEVl%pred<50%, n=84) and GOLD Ⅳ group (FEVl%pred<30%, n=51) according to GOLD classification with their general information and CT quantitative indexes recorded. Pearson correlation analysis and multiple linear regression analysis were used to explore the relationship between LAA%, pectoralis major areas (PMcsa) and lung function. The receiver operating characteristic curve (ROC curve) was used to evaluate the predictive value of LAA% and PMcsa for FEV1%pred<50% and FEV1%pred<80%. Results BMI and PMD in GOLDⅠgroup were higher than those in GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) , and the BMI in GOLD Ⅱgroup and GOLD Ⅲ group was higher than that in GOLD Ⅳ group (P<0.05) . PMcsa, PMI, FEV1%pred, FEV1 and FVC in GOLD Ⅰgroup were higher than those in GOLD Ⅱ group, GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . PMcsa, PMI, FEV1%pred, FEV1 and FVC in GOLD Ⅱ group were higher than those in GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . PMcsa, PMI , FEV1%pred, FEV1 and FVC in GOLD Ⅲ group were higher than those in GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅰ group were lower than those in GOLD Ⅱ group, GOLD Ⅲ group and GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅱ group were lower than those in GOLDⅢ group and GOLD Ⅳ group (P<0.05) . Left lung LAA%, right lung LAA% and total lung LAA% in GOLD Ⅲ group were lower than those in GOLD Ⅳ group (P<0.05) . FEV1%pred, FEV1 and FVC were positively correlated with PMcsa, PMI and PMD (P<0.05) . Both FEV1%pred and FEV1 were negatively correlated with low attenuation area ratio (right LAA%, left LAA%, total LAA%) (P<0.05) . Multiple linear regression analysis show that gender, total LAA% and PMcsa were independent influencing factors of FEV1%pred. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<50% in male patients were 0.832, 0.827, 0.834, 0.809, respectively. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<50% in female patientswere 0.844, 0.801, 0.845, 0.839, respectively. The area under ROC curve of right lung LAA%, Left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<80% in male patients were 0.830, 0.815, 0.831, 0.844, respectively. The area under ROC curve of right lung LAA%, left lung LAA%, total lung LAA% and PMcsa predicting FEV1%pred<80% in female patients were 0.805, 0.817, 0.807, 0.846, respectively. Conclusion The low attenuation area ratio and PMcsa can assess the severity of airflow restriction in elderly patients with COPD, and can be used as an important tool for early screening and severity assessment of COPD.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220263.pdfpulmonary disease, chronic obstructive|aged|respiratory function tests|tomography, spiral computed|root cause analysis|forecasting |
| spellingShingle | Yalin WANG, Jing ZHANG, Muyun ZHU Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD Zhongguo quanke yixue pulmonary disease, chronic obstructive|aged|respiratory function tests|tomography, spiral computed|root cause analysis|forecasting |
| title | Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD |
| title_full | Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD |
| title_fullStr | Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD |
| title_full_unstemmed | Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD |
| title_short | Clinical Study on Low Attenuation Area Ratio and Pectoral Major Parameters in Evaluating Severity of Pulmonary Ventilation Function Impairmentin Elderly Patients with COPD |
| title_sort | clinical study on low attenuation area ratio and pectoral major parameters in evaluating severity of pulmonary ventilation function impairmentin elderly patients with copd |
| topic | pulmonary disease, chronic obstructive|aged|respiratory function tests|tomography, spiral computed|root cause analysis|forecasting |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220263.pdf |
| work_keys_str_mv | AT yalinwangjingzhangmuyunzhu clinicalstudyonlowattenuationarearatioandpectoralmajorparametersinevaluatingseverityofpulmonaryventilationfunctionimpairmentinelderlypatientswithcopd |