Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability
Lutein is a functional carotenoid that has a wide range of physiological benefits in humans. However, it easily degrades and becomes inactivated during storage and processing, resulting in low bioavailability. The development of new nanocarriers can effectively improve the stability and biological a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.905059/full |
| _version_ | 1818149739454005248 |
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| author | He Han Yan Jiao Ying Chang Yue Cheng Lei Shi |
| author_facet | He Han Yan Jiao Ying Chang Yue Cheng Lei Shi |
| author_sort | He Han |
| collection | DOAJ |
| description | Lutein is a functional carotenoid that has a wide range of physiological benefits in humans. However, it easily degrades and becomes inactivated during storage and processing, resulting in low bioavailability. The development of new nanocarriers can effectively improve the stability and biological activity of lutein. In this study, zein hydrolysate (ZH) carriers were glycosylated with glucosamine (GLU) under the action of transglutaminase, and lutein-loaded glycosylated ZH nanoparticles (GZH-LUT) were constructed by liquid–liquid dispersion. The results showed that the GZH-LUT particles had a narrow size distribution in the range of 200–300 nm and a decreased zeta potential and polydispersity index. In particular, GZH trapped lutein more efficiently than ZH. In addition, GZH-LUT had better physical and chemical properties, including better water solubility, oxidative stability, and environmental stability than free lutein and ZH-LUT. These results indicate that glycosylated zein hydrolysate has the potential to be used as a novel protein-based nanocarrier to enhance the solubility and stability of lutein, which can further improve its bioavailability. |
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| id | doaj.art-5c0726b03d6e4fb6b60d0fb26a4c9291 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T13:11:49Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-5c0726b03d6e4fb6b60d0fb26a4c92912022-12-22T01:06:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.905059905059Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and StabilityHe HanYan JiaoYing ChangYue ChengLei ShiLutein is a functional carotenoid that has a wide range of physiological benefits in humans. However, it easily degrades and becomes inactivated during storage and processing, resulting in low bioavailability. The development of new nanocarriers can effectively improve the stability and biological activity of lutein. In this study, zein hydrolysate (ZH) carriers were glycosylated with glucosamine (GLU) under the action of transglutaminase, and lutein-loaded glycosylated ZH nanoparticles (GZH-LUT) were constructed by liquid–liquid dispersion. The results showed that the GZH-LUT particles had a narrow size distribution in the range of 200–300 nm and a decreased zeta potential and polydispersity index. In particular, GZH trapped lutein more efficiently than ZH. In addition, GZH-LUT had better physical and chemical properties, including better water solubility, oxidative stability, and environmental stability than free lutein and ZH-LUT. These results indicate that glycosylated zein hydrolysate has the potential to be used as a novel protein-based nanocarrier to enhance the solubility and stability of lutein, which can further improve its bioavailability.https://www.frontiersin.org/articles/10.3389/fphar.2022.905059/fullglycosylated zeinhydrolysatelutein nanocarrierpreparationstability |
| spellingShingle | He Han Yan Jiao Ying Chang Yue Cheng Lei Shi Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability Frontiers in Pharmacology glycosylated zein hydrolysate lutein nanocarrier preparation stability |
| title | Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability |
| title_full | Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability |
| title_fullStr | Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability |
| title_full_unstemmed | Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability |
| title_short | Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability |
| title_sort | glycosylation of zein hydrolysate as a nanocarrier for lutein delivery preparation and stability |
| topic | glycosylated zein hydrolysate lutein nanocarrier preparation stability |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.905059/full |
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