Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review
Suicidal behaviour is a public health problem whose magnitude is both substantial and increasing. Since many individuals seek medical treatment following a suicide attempt, strategies aimed at reducing further attempts in this population are a valid and feasible secondary prevention approach. An eva...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Psych |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8611/4/3/38 |
| _version_ | 1797482996795703296 |
|---|---|
| author | Ravi Philip Rajkumar |
| author_facet | Ravi Philip Rajkumar |
| author_sort | Ravi Philip Rajkumar |
| collection | DOAJ |
| description | Suicidal behaviour is a public health problem whose magnitude is both substantial and increasing. Since many individuals seek medical treatment following a suicide attempt, strategies aimed at reducing further attempts in this population are a valid and feasible secondary prevention approach. An evaluation of the available evidence suggests that existing treatment approaches have a limited efficacy in this setting, highlighting the need for innovative approaches to suicide prevention. Existing research on the neurobiology of social pain has highlighted the importance of this phenomenon as a risk factor for suicide, and has also yielded several attractive targets for pharmacological strategies that could reduce suicidality in patients with suicidal ideation or a recent attempt. In this paper, the evidence related to these targets is synthesized and critically evaluated. The way in which social pain is related to the “anti-suicidal” properties of recently approved treatments, such as ketamine and psilocybin, is examined. Such strategies may be effective for the short-term reduction in suicidal ideation and behaviour, particularly in cases where social pain is identified as a contributory factor. These pharmacological approaches may be effective regardless of the presence or absence of a specific psychiatric diagnosis, but they require careful evaluation. |
| first_indexed | 2024-03-09T22:40:33Z |
| format | Article |
| id | doaj.art-5c090f3f14cd41b9b1d91e4701ddc783 |
| institution | Directory Open Access Journal |
| issn | 2624-8611 |
| language | English |
| last_indexed | 2024-03-09T22:40:33Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Psych |
| spelling | doaj.art-5c090f3f14cd41b9b1d91e4701ddc7832023-11-23T18:39:28ZengMDPI AGPsych2624-86112022-08-014349451510.3390/psych4030038Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping ReviewRavi Philip Rajkumar0Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605 006, IndiaSuicidal behaviour is a public health problem whose magnitude is both substantial and increasing. Since many individuals seek medical treatment following a suicide attempt, strategies aimed at reducing further attempts in this population are a valid and feasible secondary prevention approach. An evaluation of the available evidence suggests that existing treatment approaches have a limited efficacy in this setting, highlighting the need for innovative approaches to suicide prevention. Existing research on the neurobiology of social pain has highlighted the importance of this phenomenon as a risk factor for suicide, and has also yielded several attractive targets for pharmacological strategies that could reduce suicidality in patients with suicidal ideation or a recent attempt. In this paper, the evidence related to these targets is synthesized and critically evaluated. The way in which social pain is related to the “anti-suicidal” properties of recently approved treatments, such as ketamine and psilocybin, is examined. Such strategies may be effective for the short-term reduction in suicidal ideation and behaviour, particularly in cases where social pain is identified as a contributory factor. These pharmacological approaches may be effective regardless of the presence or absence of a specific psychiatric diagnosis, but they require careful evaluation.https://www.mdpi.com/2624-8611/4/3/38suicidesocial painpsychacheendogenous opioid systemoxytocinserotonin |
| spellingShingle | Ravi Philip Rajkumar Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review Psych suicide social pain psychache endogenous opioid system oxytocin serotonin |
| title | Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review |
| title_full | Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review |
| title_fullStr | Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review |
| title_full_unstemmed | Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review |
| title_short | Pharmacological Strategies for Suicide Prevention Based on the Social Pain Model: A Scoping Review |
| title_sort | pharmacological strategies for suicide prevention based on the social pain model a scoping review |
| topic | suicide social pain psychache endogenous opioid system oxytocin serotonin |
| url | https://www.mdpi.com/2624-8611/4/3/38 |
| work_keys_str_mv | AT raviphiliprajkumar pharmacologicalstrategiesforsuicidepreventionbasedonthesocialpainmodelascopingreview |