Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders
Background: The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in pat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=426;epage=431;aulast= |
| _version_ | 1818585687770791936 |
|---|---|
| author | Shweta Prasad Venkateswara Reddy Reddam Albert Stezin Ravi Yadav Jitender Saini Pramod Kumar Pal |
| author_facet | Shweta Prasad Venkateswara Reddy Reddam Albert Stezin Ravi Yadav Jitender Saini Pramod Kumar Pal |
| author_sort | Shweta Prasad |
| collection | DOAJ |
| description | Background: The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in patients with PD and ICD. Objectives: This study aims to identify changes in volumes of subcortical structures and cortical thickness specific to patients with PD and ICDs. Methodology: A total of 11 patients with PD and ICD (PDICD(+)), 15 patients with PD without ICD (PDICD(−)), and 15 healthy controls were analyzed in this study. ICDs were diagnosed and quantified using the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS). Structural imaging was performed on a 3T scanner; volumes of subcortical structures and cortical thickness were obtained using first in FSL and FreeSurfer. Results: Significant volume loss of the nucleus accumbens was observed in the PDICD(+) group. Several areas of significant cortical thinning were observed in the PDICD(+) group in comparison PDICD(−) group. Thinning of the left middle temporal gyrus, transverse temporal gyrus, and bilateral temporal poles was observed in the PDICD(+) group. No correlations were observed between QUIP-RS scores and areas of cortical thinning. Conclusions: The PDICD(+) group has specific neuroanatomical variations in the nucleus accumbens and temporal lobes, which may contribute to the development of ICD and perhaps predispose a patient to ICDs on exposure to dopamine replacement therapy. |
| first_indexed | 2024-12-16T08:41:02Z |
| format | Article |
| id | doaj.art-5c099b46d7fe4a5d9cc13464a576358c |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-16T08:41:02Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-5c099b46d7fe4a5d9cc13464a576358c2022-12-21T22:37:41ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492019-01-0122442643110.4103/aian.AIAN_325_18Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disordersShweta PrasadVenkateswara Reddy ReddamAlbert StezinRavi YadavJitender SainiPramod Kumar PalBackground: The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in patients with PD and ICD. Objectives: This study aims to identify changes in volumes of subcortical structures and cortical thickness specific to patients with PD and ICDs. Methodology: A total of 11 patients with PD and ICD (PDICD(+)), 15 patients with PD without ICD (PDICD(−)), and 15 healthy controls were analyzed in this study. ICDs were diagnosed and quantified using the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS). Structural imaging was performed on a 3T scanner; volumes of subcortical structures and cortical thickness were obtained using first in FSL and FreeSurfer. Results: Significant volume loss of the nucleus accumbens was observed in the PDICD(+) group. Several areas of significant cortical thinning were observed in the PDICD(+) group in comparison PDICD(−) group. Thinning of the left middle temporal gyrus, transverse temporal gyrus, and bilateral temporal poles was observed in the PDICD(+) group. No correlations were observed between QUIP-RS scores and areas of cortical thinning. Conclusions: The PDICD(+) group has specific neuroanatomical variations in the nucleus accumbens and temporal lobes, which may contribute to the development of ICD and perhaps predispose a patient to ICDs on exposure to dopamine replacement therapy.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=426;epage=431;aulast=cortical thicknessimpulse control disorderparkinson's diseasesubcortical volumetry |
| spellingShingle | Shweta Prasad Venkateswara Reddy Reddam Albert Stezin Ravi Yadav Jitender Saini Pramod Kumar Pal Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders Annals of Indian Academy of Neurology cortical thickness impulse control disorder parkinson's disease subcortical volumetry |
| title | Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders |
| title_full | Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders |
| title_fullStr | Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders |
| title_full_unstemmed | Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders |
| title_short | Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders |
| title_sort | abnormal subcortical volumes and cortical thickness in parkinson s disease with impulse control disorders |
| topic | cortical thickness impulse control disorder parkinson's disease subcortical volumetry |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2019;volume=22;issue=4;spage=426;epage=431;aulast= |
| work_keys_str_mv | AT shwetaprasad abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders AT venkateswarareddyreddam abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders AT albertstezin abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders AT raviyadav abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders AT jitendersaini abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders AT pramodkumarpal abnormalsubcorticalvolumesandcorticalthicknessinparkinsonsdiseasewithimpulsecontroldisorders |