Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review
Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1051305/full |
| _version_ | 1828013825113194496 |
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| author | Yuanbin Song Shuzhao Chen Chenfei Liu Lezong Chen Weida Wang Bingyi Wu Yang Liang |
| author_facet | Yuanbin Song Shuzhao Chen Chenfei Liu Lezong Chen Weida Wang Bingyi Wu Yang Liang |
| author_sort | Yuanbin Song |
| collection | DOAJ |
| description | Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches. |
| first_indexed | 2024-04-10T09:50:55Z |
| format | Article |
| id | doaj.art-5c0ab6bca1034f6b972e539ab5808868 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T09:50:55Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5c0ab6bca1034f6b972e539ab58088682023-02-17T04:38:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.10513051051305Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature reviewYuanbin SongShuzhao ChenChenfei LiuLezong ChenWeida WangBingyi WuYang LiangMaintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fphar.2023.1051305/fullchemo-free maintenance therapyanti-programmed cell death protein 1histone deacetylase inhibitorT-cell acute lymphoblastic leukemiacase reportliterature review |
| spellingShingle | Yuanbin Song Shuzhao Chen Chenfei Liu Lezong Chen Weida Wang Bingyi Wu Yang Liang Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review Frontiers in Pharmacology chemo-free maintenance therapy anti-programmed cell death protein 1 histone deacetylase inhibitor T-cell acute lymphoblastic leukemia case report literature review |
| title | Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review |
| title_full | Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review |
| title_fullStr | Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review |
| title_full_unstemmed | Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review |
| title_short | Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review |
| title_sort | chemo free maintenance therapy in adult t cell acute lymphoblastic leukemia a case report and literature review |
| topic | chemo-free maintenance therapy anti-programmed cell death protein 1 histone deacetylase inhibitor T-cell acute lymphoblastic leukemia case report literature review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1051305/full |
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