The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair
Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear components, these organelles have been recently described a...
| Үндсэн зохиолчид: | , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
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Frontiers Media S.A.
2019-12-01
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| Цуврал: | Frontiers in Pharmacology |
| Нөхцлүүд: | |
| Онлайн хандалт: | https://www.frontiersin.org/article/10.3389/fphar.2019.01479/full |
| _version_ | 1828499240602566656 |
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| author | Silvia Oggero Shani Austin-Williams Lucy Victoria Norling Lucy Victoria Norling |
| author_facet | Silvia Oggero Shani Austin-Williams Lucy Victoria Norling Lucy Victoria Norling |
| author_sort | Silvia Oggero |
| collection | DOAJ |
| description | Extracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear components, these organelles have been recently described as novel regulators of intercellular communication between adjacent and remote cells. Due to their diversified composition and biological content, they portray specific signatures of cellular activation and pathological processes, their potential as diagnostic and prognostic biomarkers has raised significant interest in cardiovascular diseases. Circulating vesicles, especially those released from platelets, leukocytes, and endothelial cells are found to play a critical role in activating several fundamental cells within the vasculature, including endothelial cells and vascular smooth muscle cells. Their intrinsic activity and immunomodulatory properties lends them to not only promote vascular inflammation, but also enhance tissue regeneration, vascular repair, and indeed resolution. In this review we aim to recapitulate the recent findings concerning the roles played by EVs that originate from different circulating cells, with particular reference to their action on the endothelium. We focus herein, on the interaction of platelet and leukocyte EVs with the endothelium. In addition, their potential biological function in promoting tissue resolution and vascular repair will also be discussed. |
| first_indexed | 2024-12-11T13:21:09Z |
| format | Article |
| id | doaj.art-5c0bf3b51ff54e578d4a8721ab5d2d11 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T13:21:09Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5c0bf3b51ff54e578d4a8721ab5d2d112022-12-22T01:05:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-12-011010.3389/fphar.2019.01479499489The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue RepairSilvia Oggero0Shani Austin-Williams1Lucy Victoria Norling2Lucy Victoria Norling3William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United KingdomWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United KingdomWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United KingdomCentre for Inflammation and Therapeutic Innovation Queen Mary University of London, London, United KingdomExtracellular vesicles are a heterogeneous family of vesicles, generated from different subcellular compartments and released into the extracellular space. Composed of a lipid bilayer encompassing both soluble cytosolic material and nuclear components, these organelles have been recently described as novel regulators of intercellular communication between adjacent and remote cells. Due to their diversified composition and biological content, they portray specific signatures of cellular activation and pathological processes, their potential as diagnostic and prognostic biomarkers has raised significant interest in cardiovascular diseases. Circulating vesicles, especially those released from platelets, leukocytes, and endothelial cells are found to play a critical role in activating several fundamental cells within the vasculature, including endothelial cells and vascular smooth muscle cells. Their intrinsic activity and immunomodulatory properties lends them to not only promote vascular inflammation, but also enhance tissue regeneration, vascular repair, and indeed resolution. In this review we aim to recapitulate the recent findings concerning the roles played by EVs that originate from different circulating cells, with particular reference to their action on the endothelium. We focus herein, on the interaction of platelet and leukocyte EVs with the endothelium. In addition, their potential biological function in promoting tissue resolution and vascular repair will also be discussed.https://www.frontiersin.org/article/10.3389/fphar.2019.01479/fullextracellular vesiclesvascular inflammationendothelial celltissue resolutiontissue repair |
| spellingShingle | Silvia Oggero Shani Austin-Williams Lucy Victoria Norling Lucy Victoria Norling The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair Frontiers in Pharmacology extracellular vesicles vascular inflammation endothelial cell tissue resolution tissue repair |
| title | The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair |
| title_full | The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair |
| title_fullStr | The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair |
| title_full_unstemmed | The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair |
| title_short | The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair |
| title_sort | contrasting role of extracellular vesicles in vascular inflammation and tissue repair |
| topic | extracellular vesicles vascular inflammation endothelial cell tissue resolution tissue repair |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.01479/full |
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