Radiation-Induced Nephropathy in the Murine Model Is Ameliorated by Targeting Heparanase

Radiation-Induced Nephropathy in the Murine Model Is Ameliorated by Targeting Heparanase

Agents used to reduce adverse effects common in cancer treatment modalities do not typically possess tumor-suppressing properties. We report that heparanase, an extracellular matrix-degrading enzyme, is a promising candidate for preventing radiation nephropathy. Heparanase promotes tumor development...

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Bibliographic Details
Main Authors: Alexia Abecassis, Esther Hermano, Kim Sheva, Ariel M. Rubinstein, Michael Elkin, Amichay Meirovitz
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
heparanase
radiotherapy of cancer
pelvic malignancies
extracellular matrix
radiation nephropathy
Online Access:https://www.mdpi.com/2227-9059/11/3/710

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