Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, emotional regulation, and cognitive map creation. However, the pathological changes in the hippocampus th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1364858/full |
| _version_ | 1827276119674454016 |
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| author | Junzi Long Junzi Long Junzi Long Hui Li Hui Li Ying Liu Ying Liu Xingxing Liao Xingxing Liao Xingxing Liao Zhiqing Tang Zhiqing Tang Kaiyue Han Kaiyue Han Jiarou Chen Hao Zhang Hao Zhang Hao Zhang Hao Zhang Hao Zhang |
| author_facet | Junzi Long Junzi Long Junzi Long Hui Li Hui Li Ying Liu Ying Liu Xingxing Liao Xingxing Liao Xingxing Liao Zhiqing Tang Zhiqing Tang Kaiyue Han Kaiyue Han Jiarou Chen Hao Zhang Hao Zhang Hao Zhang Hao Zhang Hao Zhang |
| author_sort | Junzi Long |
| collection | DOAJ |
| description | The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, emotional regulation, and cognitive map creation. However, the pathological changes in the hippocampus that result in these cognitive deficits in ASD are not yet fully understood. In the present review, we will first summarize the hippocampal involvement in individuals with ASD. We will then provide an overview of hippocampal structural and functional abnormalities in genetic, environment-induced, and idiopathic animal models of ASD. Finally, we will discuss some pharmacological and non-pharmacological interventions that show positive impacts on the structure and function of the hippocampus in animal models of ASD. A further comprehension of hippocampal aberrations in ASD might elucidate their influence on the manifestation of this developmental disorder and provide clues for forthcoming diagnostic and therapeutic innovation. |
| first_indexed | 2024-04-24T06:22:35Z |
| format | Article |
| id | doaj.art-5c0cb0a55d09468da86f4a0639158139 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-24T06:22:35Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-5c0cb0a55d09468da86f4a06391581392024-04-23T04:48:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-04-011510.3389/fpsyt.2024.13648581364858Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorderJunzi Long0Junzi Long1Junzi Long2Hui Li3Hui Li4Ying Liu5Ying Liu6Xingxing Liao7Xingxing Liao8Xingxing Liao9Zhiqing Tang10Zhiqing Tang11Kaiyue Han12Kaiyue Han13Jiarou Chen14Hao Zhang15Hao Zhang16Hao Zhang17Hao Zhang18Hao Zhang19School of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaDivision of Brain Sciences, Changping Laboratory, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaCheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaDivision of Brain Sciences, Changping Laboratory, Beijing, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaSchool of Rehabilitation, Capital Medical University, Beijing, ChinaDepartment of Neurorehabilitation, China Rehabilitation Research Center, Beijing, ChinaDivision of Brain Sciences, Changping Laboratory, Beijing, ChinaCheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, emotional regulation, and cognitive map creation. However, the pathological changes in the hippocampus that result in these cognitive deficits in ASD are not yet fully understood. In the present review, we will first summarize the hippocampal involvement in individuals with ASD. We will then provide an overview of hippocampal structural and functional abnormalities in genetic, environment-induced, and idiopathic animal models of ASD. Finally, we will discuss some pharmacological and non-pharmacological interventions that show positive impacts on the structure and function of the hippocampus in animal models of ASD. A further comprehension of hippocampal aberrations in ASD might elucidate their influence on the manifestation of this developmental disorder and provide clues for forthcoming diagnostic and therapeutic innovation.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1364858/fullautism spectrum disorder (ASD)hippocampuslearningmemorycognitive mapanxiety |
| spellingShingle | Junzi Long Junzi Long Junzi Long Hui Li Hui Li Ying Liu Ying Liu Xingxing Liao Xingxing Liao Xingxing Liao Zhiqing Tang Zhiqing Tang Kaiyue Han Kaiyue Han Jiarou Chen Hao Zhang Hao Zhang Hao Zhang Hao Zhang Hao Zhang Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder Frontiers in Psychiatry autism spectrum disorder (ASD) hippocampus learning memory cognitive map anxiety |
| title | Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder |
| title_full | Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder |
| title_fullStr | Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder |
| title_full_unstemmed | Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder |
| title_short | Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder |
| title_sort | insights into the structure and function of the hippocampus implications for the pathophysiology and treatment of autism spectrum disorder |
| topic | autism spectrum disorder (ASD) hippocampus learning memory cognitive map anxiety |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1364858/full |
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