Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES
Abstract Background Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitamin D (25(OH)D) and all-cause and cause-specific mortality among postmeno...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-023-04413-y |
| _version_ | 1827633333699346432 |
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| author | Jia-Wei Shi Jiang-Nan Wu Xiao-Yong Zhu Wen-Hui Zhou Jin-Ying Yang Ming-Qing Li |
| author_facet | Jia-Wei Shi Jiang-Nan Wu Xiao-Yong Zhu Wen-Hui Zhou Jin-Ying Yang Ming-Qing Li |
| author_sort | Jia-Wei Shi |
| collection | DOAJ |
| description | Abstract Background Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitamin D (25(OH)D) and all-cause and cause-specific mortality among postmenopausal women in the United States. Methods 6812 participants of postmenopausal females from the National Health and Nutrition Examination Survey (2001–2018) were included in this study. The mortality status of the follow-up was ascertained by linkage to National Death Index (NDI) records through 31 December 2019. We used cox proportional hazards models to estimate the association of serum 25(OH)D concentrations and mortality of postmenopausal females. Results The mean level of serum 25(OH)D was 72.57 ± 29.93 nmol/L, and 65.34% had insufficient vitamin D. In postmenopausal females, low serum 25(OH)D concentrations were significantly associated with higher levels of glycohemoglobin, glucose, and lower levels of HDL. During follow-up, 1448 all-cause deaths occurred, including 393 cardiovascular disease (CVD)-related deaths and 263 cancer deaths. After multivariate adjustment, higher serum 25(OH)D levels were significantly related with lower all-cause and CVD mortality. In addition, serum 25(OH)D presented a L-shaped relationship with all-cause mortality, while appeared a U-shaped with CVD mortality, and the cut-off value is 73.89 nmol/L and 46.75 nmol/L respectively. Conclusions Low serum 25(OH)D levels are associated with the higher risk of all-cause and CVD mortality in postmenopausal females. These findings provide new ideas and targets for the health management of postmenopausal women. |
| first_indexed | 2024-03-09T14:58:05Z |
| format | Article |
| id | doaj.art-5c0ccf5be75d457b9874025bb206b7bb |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-09T14:58:05Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-5c0ccf5be75d457b9874025bb206b7bb2023-11-26T14:04:10ZengBMCJournal of Translational Medicine1479-58762023-09-0121111110.1186/s12967-023-04413-yAssociation of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANESJia-Wei Shi0Jiang-Nan Wu1Xiao-Yong Zhu2Wen-Hui Zhou3Jin-Ying Yang4Ming-Qing Li5Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan UniversityClinical Epidemiology, Hospital of Obstetrics and Gynecology, Fudan UniversityShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan UniversityMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical UniversityLonggang District Maternity &, Child Healthcare Hospital of Shenzhen City, Longgang Maternity and Child Institute of Shantou University Medical CollegeShanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan UniversityAbstract Background Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitamin D (25(OH)D) and all-cause and cause-specific mortality among postmenopausal women in the United States. Methods 6812 participants of postmenopausal females from the National Health and Nutrition Examination Survey (2001–2018) were included in this study. The mortality status of the follow-up was ascertained by linkage to National Death Index (NDI) records through 31 December 2019. We used cox proportional hazards models to estimate the association of serum 25(OH)D concentrations and mortality of postmenopausal females. Results The mean level of serum 25(OH)D was 72.57 ± 29.93 nmol/L, and 65.34% had insufficient vitamin D. In postmenopausal females, low serum 25(OH)D concentrations were significantly associated with higher levels of glycohemoglobin, glucose, and lower levels of HDL. During follow-up, 1448 all-cause deaths occurred, including 393 cardiovascular disease (CVD)-related deaths and 263 cancer deaths. After multivariate adjustment, higher serum 25(OH)D levels were significantly related with lower all-cause and CVD mortality. In addition, serum 25(OH)D presented a L-shaped relationship with all-cause mortality, while appeared a U-shaped with CVD mortality, and the cut-off value is 73.89 nmol/L and 46.75 nmol/L respectively. Conclusions Low serum 25(OH)D levels are associated with the higher risk of all-cause and CVD mortality in postmenopausal females. These findings provide new ideas and targets for the health management of postmenopausal women.https://doi.org/10.1186/s12967-023-04413-y25-hydroxyvitamin DPostmenopausal femaleMortalityCardiovascular diseaseCancer |
| spellingShingle | Jia-Wei Shi Jiang-Nan Wu Xiao-Yong Zhu Wen-Hui Zhou Jin-Ying Yang Ming-Qing Li Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES Journal of Translational Medicine 25-hydroxyvitamin D Postmenopausal female Mortality Cardiovascular disease Cancer |
| title | Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES |
| title_full | Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES |
| title_fullStr | Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES |
| title_full_unstemmed | Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES |
| title_short | Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES |
| title_sort | association of serum 25 hydroxyvitamin d levels with all cause and cause specific mortality among postmenopausal females results from nhanes |
| topic | 25-hydroxyvitamin D Postmenopausal female Mortality Cardiovascular disease Cancer |
| url | https://doi.org/10.1186/s12967-023-04413-y |
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