Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study
Background: Intracranial artery dissection (IAD) is a pathological dissection of the arterial wall. .However, the morphological features and imaging characteristics of patients with intracranial artery dissection (IAD) remain poorly understood. Methods: The study reports on 70 IAD patients (30 culpr...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-09-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106157 |
| _version_ | 1828119369078538240 |
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| author | Qin Wu Yigang Liu Boheng Duan Xiaoru Yuan Zheng Zuo Feng Ouyang Mingxue Yin Ye Chen Xianjun Zeng |
| author_facet | Qin Wu Yigang Liu Boheng Duan Xiaoru Yuan Zheng Zuo Feng Ouyang Mingxue Yin Ye Chen Xianjun Zeng |
| author_sort | Qin Wu |
| collection | DOAJ |
| description | Background: Intracranial artery dissection (IAD) is a pathological dissection of the arterial wall. .However, the morphological features and imaging characteristics of patients with intracranial artery dissection (IAD) remain poorly understood. Methods: The study reports on 70 IAD patients (30 culprit and 40 non-culprit). All participants underwent high-resolution magnetic resonance imaging (HR-MRI) scans. The morphological features and imaging characteristics of artery dissection were carefully investigated. Demographics and clinical characteristics of culprit and non-culprit patients were also collected. Apparent differences between the two groups, which could be used as biomarkers for ischemic event caused by the culprit dissection, were identified by receiver operating characteristic (ROC) curve analysis. Results: The IAD patients studied could be classified into five different types on the basis of morphological features: classical dissection (n = 31), fusiform aneurysm (n = 2), long dissected aneurysm (n = 9), dolichoectatic dissecting aneurysm (n = 6), and saccular aneurysm (n = 22). The direct sites of artery dissection (double lumen and intimal flap) can be seen in most IAD patients on HR-MRI. Additionally, the presence of hypertension, double lumen and intimal flap were associated with culprit lesions and might be considered biomarkers for the ischemic event caused by the culprit dissection. Conclusions: Analysis showed that HR-MRI allowed easy visualization of abnormal morphology of artery dissection lesions. This was of great significance for the diagnosis of IAD and gave a better understanding of its pathophysiological mechanism. |
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| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-04-11T13:48:22Z |
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| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-5c0e9d2344534e509f24d8348c9559d52022-12-22T04:20:54ZengIMR PressJournal of Integrative Neuroscience0219-63522022-09-0121615710.31083/j.jin2106157S0219-6352(22)00459-4Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI StudyQin Wu0Yigang Liu1Boheng Duan2Xiaoru Yuan3Zheng Zuo4Feng Ouyang5Mingxue Yin6Ye Chen7Xianjun Zeng8Department of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Ultrasound, Jiangxi Cancer Hospital, 330029 Nanchang, Jiangxi, ChinaClass 211, Innovation Experiment, Nanchang University, 330031 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaBackground: Intracranial artery dissection (IAD) is a pathological dissection of the arterial wall. .However, the morphological features and imaging characteristics of patients with intracranial artery dissection (IAD) remain poorly understood. Methods: The study reports on 70 IAD patients (30 culprit and 40 non-culprit). All participants underwent high-resolution magnetic resonance imaging (HR-MRI) scans. The morphological features and imaging characteristics of artery dissection were carefully investigated. Demographics and clinical characteristics of culprit and non-culprit patients were also collected. Apparent differences between the two groups, which could be used as biomarkers for ischemic event caused by the culprit dissection, were identified by receiver operating characteristic (ROC) curve analysis. Results: The IAD patients studied could be classified into five different types on the basis of morphological features: classical dissection (n = 31), fusiform aneurysm (n = 2), long dissected aneurysm (n = 9), dolichoectatic dissecting aneurysm (n = 6), and saccular aneurysm (n = 22). The direct sites of artery dissection (double lumen and intimal flap) can be seen in most IAD patients on HR-MRI. Additionally, the presence of hypertension, double lumen and intimal flap were associated with culprit lesions and might be considered biomarkers for the ischemic event caused by the culprit dissection. Conclusions: Analysis showed that HR-MRI allowed easy visualization of abnormal morphology of artery dissection lesions. This was of great significance for the diagnosis of IAD and gave a better understanding of its pathophysiological mechanism.https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106157intracranial artery dissectionhigh-resolution magnetic resonance imagingischemic event |
| spellingShingle | Qin Wu Yigang Liu Boheng Duan Xiaoru Yuan Zheng Zuo Feng Ouyang Mingxue Yin Ye Chen Xianjun Zeng Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study Journal of Integrative Neuroscience intracranial artery dissection high-resolution magnetic resonance imaging ischemic event |
| title | Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study |
| title_full | Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study |
| title_fullStr | Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study |
| title_full_unstemmed | Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study |
| title_short | Assessment of Morphological Features and Imaging Characteristics of Patients with Intracranial Artery Dissection: A High-Resolution MRI Study |
| title_sort | assessment of morphological features and imaging characteristics of patients with intracranial artery dissection a high resolution mri study |
| topic | intracranial artery dissection high-resolution magnetic resonance imaging ischemic event |
| url | https://www.imrpress.com/journal/JIN/21/6/10.31083/j.jin2106157 |
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