Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children
The objective of the study was to verify whether or not FTO rs9939609, rs9926289 and TMEM18 rs4854344, rs6548238, rs2867125 variants are important risk factors for overweight and/or obesity in Polish children aged 6-16 (n=283). FTO rs 9939609 and rs9926289 exhibited a strong codominant obesity-predi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Lodz University Press
2016-03-01
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| Series: | Anthropological Review |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/anre-2016-0002 |
| _version_ | 1797718609138548736 |
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| author | Rosset Iwona Strapagiel Dominik Sitek Aneta Majewska Małgorzata Ostrowska-Nawarycz Lidia Żądzińska Elżbieta |
| author_facet | Rosset Iwona Strapagiel Dominik Sitek Aneta Majewska Małgorzata Ostrowska-Nawarycz Lidia Żądzińska Elżbieta |
| author_sort | Rosset Iwona |
| collection | DOAJ |
| description | The objective of the study was to verify whether or not FTO rs9939609, rs9926289 and TMEM18 rs4854344, rs6548238, rs2867125 variants are important risk factors for overweight and/or obesity in Polish children aged 6-16 (n=283). FTO rs 9939609 and rs9926289 exhibited a strong codominant obesity-predisposing effect of genotypes homozygous for minor alleles (OR=5.42, 95% CI: 2.04-14.39, p=0.0006). The important finding of the study is increased risk of overweight (OR=5.03, 95% CI: 1.15-21.93, p=0.0306) in individuals homozygous for the minor alleles rs4854344, rs6548238 and rs2867125 in the recessive inheritance model, while no other significant associations between TMEM18 variants and risk of obesity were found. Given the identified interaction TMEM18 genotype × BMI category (p=0.0077), it seems that the effect of homozygous for the minor alleles may be compared to a “weight guard”, which significantly increases the risk of overweight, but not of obesity, because it promotes weight gain only up to the threshold of obesity. Conclusion: The proposed hypothetical effect (“weight guard”) of homozygous for the minor alleles in the TMEM18 based on a rather small sample is a possible explanation of the effects of minor alleles, which minimize the risk of obesity. |
| first_indexed | 2024-03-12T08:52:51Z |
| format | Article |
| id | doaj.art-5c0fd1a1947940d49e2984799673d046 |
| institution | Directory Open Access Journal |
| issn | 2083-4594 |
| language | English |
| last_indexed | 2024-03-12T08:52:51Z |
| publishDate | 2016-03-01 |
| publisher | Lodz University Press |
| record_format | Article |
| series | Anthropological Review |
| spelling | doaj.art-5c0fd1a1947940d49e2984799673d0462023-09-02T16:15:53ZengLodz University PressAnthropological Review2083-45942016-03-01791173310.1515/anre-2016-0002anre-2016-0002Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish childrenRosset Iwona0Strapagiel Dominik1Sitek Aneta2Majewska Małgorzata3Ostrowska-Nawarycz Lidia4Żądzińska Elżbieta5Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, PolandBiobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, PolandDepartment of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, PolandDepartment of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, PolandDepartment of Biophysics, Chair of Basic and Pre-clinical Sciences, Medical University of Łódź, PolandDepartment of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, PolandThe objective of the study was to verify whether or not FTO rs9939609, rs9926289 and TMEM18 rs4854344, rs6548238, rs2867125 variants are important risk factors for overweight and/or obesity in Polish children aged 6-16 (n=283). FTO rs 9939609 and rs9926289 exhibited a strong codominant obesity-predisposing effect of genotypes homozygous for minor alleles (OR=5.42, 95% CI: 2.04-14.39, p=0.0006). The important finding of the study is increased risk of overweight (OR=5.03, 95% CI: 1.15-21.93, p=0.0306) in individuals homozygous for the minor alleles rs4854344, rs6548238 and rs2867125 in the recessive inheritance model, while no other significant associations between TMEM18 variants and risk of obesity were found. Given the identified interaction TMEM18 genotype × BMI category (p=0.0077), it seems that the effect of homozygous for the minor alleles may be compared to a “weight guard”, which significantly increases the risk of overweight, but not of obesity, because it promotes weight gain only up to the threshold of obesity. Conclusion: The proposed hypothetical effect (“weight guard”) of homozygous for the minor alleles in the TMEM18 based on a rather small sample is a possible explanation of the effects of minor alleles, which minimize the risk of obesity.https://doi.org/10.1515/anre-2016-0002body mass indexobesity-and overweight-associated geneftotmem18polish population |
| spellingShingle | Rosset Iwona Strapagiel Dominik Sitek Aneta Majewska Małgorzata Ostrowska-Nawarycz Lidia Żądzińska Elżbieta Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children Anthropological Review body mass index obesity-and overweight-associated gene fto tmem18 polish population |
| title | Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children |
| title_full | Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children |
| title_fullStr | Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children |
| title_full_unstemmed | Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children |
| title_short | Association of FTO and TMEM18 polymorphisms with overweight and obesity in the population of Polish children |
| title_sort | association of fto and tmem18 polymorphisms with overweight and obesity in the population of polish children |
| topic | body mass index obesity-and overweight-associated gene fto tmem18 polish population |
| url | https://doi.org/10.1515/anre-2016-0002 |
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