Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice
This study aimed to investigate pathology of oral E. cuniculi infection during pregnancy in pregnant mice and embryos. A total of 40 pregnant mice at first day of gestation were divided into two groups, first group were infected orally by E. cuniculi sores of 107 spores/ mice, second group left...
| Main Authors: | , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
University of Mosul, College of Veterinary Medicine
2016-12-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://www.vetmedmosul.org/ijvs/media/16-2-5e.pdf |
| _version_ | 1818144205136986112 |
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| author | S.S. Al-Mahmood H.I. Al-Sadi |
| author_facet | S.S. Al-Mahmood H.I. Al-Sadi |
| author_sort | S.S. Al-Mahmood |
| collection | DOAJ |
| description | This study aimed to investigate pathology of oral E. cuniculi infection during pregnancy in pregnant mice and embryos. A
total of 40 pregnant mice at first day of gestation were divided into two groups, first group were infected orally by E. cuniculi
sores of 107
spores/ mice, second group left without any treatment. At 18th days of gestation all pregnant mice were euthanized.
Gross pathology finding in pregnant mice of infected group included congestion of liver and lung, the embryos lesions
consisted from enlargement of head and abdomen. Histological lesions in pregnant mice of infected group consisted of hepatic
non-suppurative granulomatous lesions with E. cuniculi spores aggregation with lymphocytic infiltration, the lungs lesions
consisted of infiltration of lymphocytes with E. cuniculi spores, kidney lesions composed from degenerative and necrotic
changes in renal tubules, brain lesions consisted from lymphocytic infiltration with increase in number of glial cells, while
intestine tissue sections showed hyperplasia of lymphatic tissue with present of parasitic vacuoles at tips of villi, the placenta
exhibited E. cuniculi spores with hyperplasia of trophoblast in chorionic villi, while histological lesions in embryos showed
lymphocytic infiltration around alveoli with hyperplasia of lymphatic tissue around bronchioles with absent the normal
architecture of hepatic cords and vacuolation of hepatocytes with hyperplasia of lymphocytes in white pulp of spleen. This
study provides insight into the pathology of E. cuniculi infection in pregnant mice and their embryos, also supports the
hypothesis of intrauterine transmission of E. cuniculi infection to embryos during pregnancy period. |
| first_indexed | 2024-12-11T11:43:51Z |
| format | Article |
| id | doaj.art-5c10d9cc40fd464ca339087b02f6c9a0 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-11T11:43:51Z |
| publishDate | 2016-12-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-5c10d9cc40fd464ca339087b02f6c9a02022-12-22T01:08:32ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552016-12-0130 English24954Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant miceS.S. Al-Mahmood0H.I. Al-Sadi1 University of Mosul, Mosul, Iraq University of Mosul, Mosul, IraqThis study aimed to investigate pathology of oral E. cuniculi infection during pregnancy in pregnant mice and embryos. A total of 40 pregnant mice at first day of gestation were divided into two groups, first group were infected orally by E. cuniculi sores of 107 spores/ mice, second group left without any treatment. At 18th days of gestation all pregnant mice were euthanized. Gross pathology finding in pregnant mice of infected group included congestion of liver and lung, the embryos lesions consisted from enlargement of head and abdomen. Histological lesions in pregnant mice of infected group consisted of hepatic non-suppurative granulomatous lesions with E. cuniculi spores aggregation with lymphocytic infiltration, the lungs lesions consisted of infiltration of lymphocytes with E. cuniculi spores, kidney lesions composed from degenerative and necrotic changes in renal tubules, brain lesions consisted from lymphocytic infiltration with increase in number of glial cells, while intestine tissue sections showed hyperplasia of lymphatic tissue with present of parasitic vacuoles at tips of villi, the placenta exhibited E. cuniculi spores with hyperplasia of trophoblast in chorionic villi, while histological lesions in embryos showed lymphocytic infiltration around alveoli with hyperplasia of lymphatic tissue around bronchioles with absent the normal architecture of hepatic cords and vacuolation of hepatocytes with hyperplasia of lymphocytes in white pulp of spleen. This study provides insight into the pathology of E. cuniculi infection in pregnant mice and their embryos, also supports the hypothesis of intrauterine transmission of E. cuniculi infection to embryos during pregnancy period.http://www.vetmedmosul.org/ijvs/media/16-2-5e.pdfEmbryosEncephalitozoon cuniculiIntrauterine InfectionPregnant Mice |
| spellingShingle | S.S. Al-Mahmood H.I. Al-Sadi Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice Iraqi Journal of Veterinary Sciences Embryos Encephalitozoon cuniculi Intrauterine Infection Pregnant Mice |
| title | Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice |
| title_full | Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice |
| title_fullStr | Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice |
| title_full_unstemmed | Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice |
| title_short | Pathological study of intrauterine infection to embryos by Encephalitozoon cuniculi spores in pregnant mice |
| title_sort | pathological study of intrauterine infection to embryos by encephalitozoon cuniculi spores in pregnant mice |
| topic | Embryos Encephalitozoon cuniculi Intrauterine Infection Pregnant Mice |
| url | http://www.vetmedmosul.org/ijvs/media/16-2-5e.pdf |
| work_keys_str_mv | AT ssalmahmood pathologicalstudyofintrauterineinfectiontoembryosbyencephalitozooncuniculisporesinpregnantmice AT hialsadi pathologicalstudyofintrauterineinfectiontoembryosbyencephalitozooncuniculisporesinpregnantmice |