Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction
AimsLeft ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.786509/full |
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| author | Camilla Calvieri Nicola Galea Nicola Galea Francesco Cilia Giacomo Pambianchi Giuseppe Mancuso Domenico Filomena Sara Cimino Iacopo Carbone Marco Francone Marco Francone Luciano Agati Carlo Catalano |
| author_facet | Camilla Calvieri Nicola Galea Nicola Galea Francesco Cilia Giacomo Pambianchi Giuseppe Mancuso Domenico Filomena Sara Cimino Iacopo Carbone Marco Francone Marco Francone Luciano Agati Carlo Catalano |
| author_sort | Camilla Calvieri |
| collection | DOAJ |
| description | AimsLeft ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This study aimed to evaluate the role of myocardial strain parameters in predicting LV remodeling and to investigate the effect of Aspirin (ASA) dose before primary coronary angioplasty (pPCI) on myocardial injury and early LV remodeling.Methods and ResultsSeventy-eight patients undergoing CMR, within 9 days from symptom onset and after 6 months, were enrolled in this cohort retrospective study. We divided the study population into three groups based on a revised Bullock's classification and we evaluated the role of baseline CMR features in predicting early LV remodeling. Regarding CMR strain analysis, worse global circumferential and longitudinal strain (GCS and GLS) values were associated with adverse LV remodeling. Patients were also divided based on pre-pPCI ASA dosage. Significant differences were detected in patients receiving ASA 500 mg dose before pPCI, which showed lower infarct size extent and better strain values compared to those treated with ASA 250 mg. The stepwise multivariate logistic regression analysis, adjusted for covariates, indicated that a 500 mg ASA dose remained an inverse independent predictor of early adverse LV remodeling.ConclusionGCS and GLS have high specificity to detect early LV adverse remodeling. We first reported a protective effect of ASA loading dose of 500 mg before pPCI on LV myocardial damage and in reducing early LV adverse remodeling. |
| first_indexed | 2024-12-13T15:11:41Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T15:11:41Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5c1177cf023a4261b7ee428c1eb109ca2022-12-21T23:40:51ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.786509786509Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial InfarctionCamilla Calvieri0Nicola Galea1Nicola Galea2Francesco Cilia3Giacomo Pambianchi4Giuseppe Mancuso5Domenico Filomena6Sara Cimino7Iacopo Carbone8Marco Francone9Marco Francone10Luciano Agati11Carlo Catalano12Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, “Policlinico Umberto I” Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, “Policlinico Umberto I” Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, “Policlinico Umberto I” Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyHumanitas Research Hospital, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, ItalyDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, “Policlinico Umberto I” Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, ItalyAimsLeft ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is a complex process, defined as changes of LV volumes over time. CMR feature tracking analysis (CMR-FT) offers an accurate quantitative assessment of LV wall deformation and myocardial contractile function. This study aimed to evaluate the role of myocardial strain parameters in predicting LV remodeling and to investigate the effect of Aspirin (ASA) dose before primary coronary angioplasty (pPCI) on myocardial injury and early LV remodeling.Methods and ResultsSeventy-eight patients undergoing CMR, within 9 days from symptom onset and after 6 months, were enrolled in this cohort retrospective study. We divided the study population into three groups based on a revised Bullock's classification and we evaluated the role of baseline CMR features in predicting early LV remodeling. Regarding CMR strain analysis, worse global circumferential and longitudinal strain (GCS and GLS) values were associated with adverse LV remodeling. Patients were also divided based on pre-pPCI ASA dosage. Significant differences were detected in patients receiving ASA 500 mg dose before pPCI, which showed lower infarct size extent and better strain values compared to those treated with ASA 250 mg. The stepwise multivariate logistic regression analysis, adjusted for covariates, indicated that a 500 mg ASA dose remained an inverse independent predictor of early adverse LV remodeling.ConclusionGCS and GLS have high specificity to detect early LV adverse remodeling. We first reported a protective effect of ASA loading dose of 500 mg before pPCI on LV myocardial damage and in reducing early LV adverse remodeling.https://www.frontiersin.org/articles/10.3389/fcvm.2022.786509/fullmyocardial infarctionfeature trackingcardiac magnetic resonancemyocardial strainaspirinventricular remodeling |
| spellingShingle | Camilla Calvieri Nicola Galea Nicola Galea Francesco Cilia Giacomo Pambianchi Giuseppe Mancuso Domenico Filomena Sara Cimino Iacopo Carbone Marco Francone Marco Francone Luciano Agati Carlo Catalano Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction Frontiers in Cardiovascular Medicine myocardial infarction feature tracking cardiac magnetic resonance myocardial strain aspirin ventricular remodeling |
| title | Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction |
| title_full | Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction |
| title_fullStr | Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction |
| title_full_unstemmed | Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction |
| title_short | Protective Value of Aspirin Loading Dose on Left Ventricular Remodeling After ST-Elevation Myocardial Infarction |
| title_sort | protective value of aspirin loading dose on left ventricular remodeling after st elevation myocardial infarction |
| topic | myocardial infarction feature tracking cardiac magnetic resonance myocardial strain aspirin ventricular remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.786509/full |
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