Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways

Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways

Abstract Background Obesity is a negative chronic metabolic health condition that represents an additional risk for the development of multiple pathologies. Epidemiological studies have shown how maternal obesity or gestational diabetes mellitus during pregnancy constitute serious risk factors in re...

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Main Authors: Juan José Alba-Linares, Raúl F. Pérez, Juan Ramón Tejedor, David Bastante-Rodríguez, Francisco Ponce, Nuria García Carbonell, Rafael Gómez Zafra, Agustín F. Fernández, Mario F. Fraga, Empar Lurbe
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cardiovascular Diabetology
Subjects:
Metabolism
DNA methylation
Epigenetics
Obesity
Gestational diabetes
Newborn
Online Access:https://doi.org/10.1186/s12933-023-01774-y

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