Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA)

Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA)

In patients with melanoma brain metastases (MBM), a combination of radiotherapy (RT) with immune checkpoint inhibitors (ICI) is routinely used. However, the best sequence of radio-immunotherapy (RIT) remains unclear. In an exploratory phase 2 trial, MBM patients received RT (stereotactic or whole-br...

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Bibliographic Details
Main Authors: Jessica C. Hassel, Timo E. Schank, Heiko Smetak, Jasmin Mühlbauer, Martin Salzmann, Devayani Machiraju, Christian Menzer, Kristin Lang, Laila König, Matthias F. Haefner, Ingrid Hülsmeyer, Christian Kohler, Rainer Spang, Alexander Enk, Jürgen Debus, Philipp Beckhove
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Melanoma
brain metastases
radiation
immune checkpoint inhibitors
treatment sequence
immune monitoring
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2066609

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