Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair
Purpose The objective of this study was to determine mechanical and histological properties of Phasix™ ST Mesh in various defect sizes and characterize the tissue replacing Phasix™ ST Mesh in a porcine model of ventral hernia repair. Methods Simulated hernia defects were surgically created in the mi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2020.1830318 |
| _version_ | 1797684468401569792 |
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| author | Corey R. Deeken Darcy H. Gagne Amit Badhwar |
| author_facet | Corey R. Deeken Darcy H. Gagne Amit Badhwar |
| author_sort | Corey R. Deeken |
| collection | DOAJ |
| description | Purpose The objective of this study was to determine mechanical and histological properties of Phasix™ ST Mesh in various defect sizes and characterize the tissue replacing Phasix™ ST Mesh in a porcine model of ventral hernia repair. Methods Simulated hernia defects were surgically created in the midline of twenty-four (n = 24) Yucatan pigs. Treatment groups included 8 cm defect sutured closed (buttress) and unclosed 4 cm and 8 cm defect groups. Phasix™ ST Mesh (15 cm diameter circle) was implanted laparoscopically and fixated circumferentially with SorbaFix™ Absorbable Fixation System fasteners. The repair sites underwent mechanical, molecular weight, and histological evaluation at 48 and 72 weeks postimplantation. Results Mechanical testing of Phasix™ ST Mesh-repaired sites revealed similar strengths at both time points for all three repair types, p > 0.05 in all cases (48 weeks: 142.4 ± 6.0 N, 142.3 ± 16.5 N, and 168.8 ± 38.5 N; 72 weeks: 110.0 ± 18.3 N, 138.6 ± 42.2 N, and 160.6 ± 42.0 N for 4 cm defect, 8 cm defect, and 8 cm buttress, respectively. mean ± SEM) No significant differences were observed over time except at 72 weeks postimplantation when the 4 cm defect group exhibited significantly lower strength than the T0 strength of Phasix™ ST Mesh (204.6 ± 5.0 N, p < 0.05). The molecular weight of Phasix™ ST Mesh decreased over time, regardless of repair type. Histological analysis showed comparable mature collagen/fibrovascular tissue around and within the Phasix™ ST Mesh interstices, including the segment of mesh overlying the defect. Conclusion Phasix™ ST Mesh-repaired sites exhibited similar mechanical strengths and histological properties across all defect sizes in this porcine model. |
| first_indexed | 2024-03-12T00:31:09Z |
| format | Article |
| id | doaj.art-5c148743dd8c463a9805ccc9474a138e |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:31:09Z |
| publishDate | 2022-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-5c148743dd8c463a9805ccc9474a138e2023-09-15T10:21:27ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-02-0135241542310.1080/08941939.2020.18303181830318Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia RepairCorey R. Deeken0Darcy H. Gagne1Amit Badhwar2Covalent Bio LLCBecton, Dickinson and Company (BD)Becton, Dickinson and Company (BD)Purpose The objective of this study was to determine mechanical and histological properties of Phasix™ ST Mesh in various defect sizes and characterize the tissue replacing Phasix™ ST Mesh in a porcine model of ventral hernia repair. Methods Simulated hernia defects were surgically created in the midline of twenty-four (n = 24) Yucatan pigs. Treatment groups included 8 cm defect sutured closed (buttress) and unclosed 4 cm and 8 cm defect groups. Phasix™ ST Mesh (15 cm diameter circle) was implanted laparoscopically and fixated circumferentially with SorbaFix™ Absorbable Fixation System fasteners. The repair sites underwent mechanical, molecular weight, and histological evaluation at 48 and 72 weeks postimplantation. Results Mechanical testing of Phasix™ ST Mesh-repaired sites revealed similar strengths at both time points for all three repair types, p > 0.05 in all cases (48 weeks: 142.4 ± 6.0 N, 142.3 ± 16.5 N, and 168.8 ± 38.5 N; 72 weeks: 110.0 ± 18.3 N, 138.6 ± 42.2 N, and 160.6 ± 42.0 N for 4 cm defect, 8 cm defect, and 8 cm buttress, respectively. mean ± SEM) No significant differences were observed over time except at 72 weeks postimplantation when the 4 cm defect group exhibited significantly lower strength than the T0 strength of Phasix™ ST Mesh (204.6 ± 5.0 N, p < 0.05). The molecular weight of Phasix™ ST Mesh decreased over time, regardless of repair type. Histological analysis showed comparable mature collagen/fibrovascular tissue around and within the Phasix™ ST Mesh interstices, including the segment of mesh overlying the defect. Conclusion Phasix™ ST Mesh-repaired sites exhibited similar mechanical strengths and histological properties across all defect sizes in this porcine model.http://dx.doi.org/10.1080/08941939.2020.1830318absorbablebiologically-derivedhernia repairmeshphasix™ st meshpoly-4-hydroxybutyrate |
| spellingShingle | Corey R. Deeken Darcy H. Gagne Amit Badhwar Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair Journal of Investigative Surgery absorbable biologically-derived hernia repair mesh phasix™ st mesh poly-4-hydroxybutyrate |
| title | Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair |
| title_full | Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair |
| title_fullStr | Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair |
| title_full_unstemmed | Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair |
| title_short | Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair |
| title_sort | mechanical and histological characteristics of phasix™ st mesh in a porcine model of hernia repair |
| topic | absorbable biologically-derived hernia repair mesh phasix™ st mesh poly-4-hydroxybutyrate |
| url | http://dx.doi.org/10.1080/08941939.2020.1830318 |
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