Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses
The development of depressive disorders had long been attributed to monoamine variations, and pharmacological treatment strategies likewise focused on methods of altering monoamine availability. However, the limited success achieved by treatments that altered these processes spurred the search for a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00068/full |
| _version_ | 1811303563250368512 |
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| author | Marie-Claude eAudet Hymie eAnisman |
| author_facet | Marie-Claude eAudet Hymie eAnisman |
| author_sort | Marie-Claude eAudet |
| collection | DOAJ |
| description | The development of depressive disorders had long been attributed to monoamine variations, and pharmacological treatment strategies likewise focused on methods of altering monoamine availability. However, the limited success achieved by treatments that altered these processes spurred the search for alternative mechanisms and treatments. Here we provide a brief overview concerning a possible role for pro-inflammatory cytokines and growth factors in major depression, as well as the possibility of targeting these factors in treating this disorder. The data suggest that focusing on one or another cytokine or growth factor might be counterproductive, especially as these factors may act sequentially or in parallel in affecting depressive disorders. It is also suggested that cytokines and growth factors might be useful biomarkers for individualized treatments of depressive illnesses. |
| first_indexed | 2024-04-13T07:48:57Z |
| format | Article |
| id | doaj.art-5c171f5959b9461fa96efef1d856f98c |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T07:48:57Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-5c171f5959b9461fa96efef1d856f98c2022-12-22T02:55:35ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-05-01710.3389/fncel.2013.0006847084Interplay between pro-inflammatory cytokines and growth factors in depressive illnessesMarie-Claude eAudet0Hymie eAnisman1Carleton UniversityCarleton UniversityThe development of depressive disorders had long been attributed to monoamine variations, and pharmacological treatment strategies likewise focused on methods of altering monoamine availability. However, the limited success achieved by treatments that altered these processes spurred the search for alternative mechanisms and treatments. Here we provide a brief overview concerning a possible role for pro-inflammatory cytokines and growth factors in major depression, as well as the possibility of targeting these factors in treating this disorder. The data suggest that focusing on one or another cytokine or growth factor might be counterproductive, especially as these factors may act sequentially or in parallel in affecting depressive disorders. It is also suggested that cytokines and growth factors might be useful biomarkers for individualized treatments of depressive illnesses.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00068/fullDepressionBDNFPro-inflammatory cytokinesAntidepressantsgrowth factorsstressors |
| spellingShingle | Marie-Claude eAudet Hymie eAnisman Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses Frontiers in Cellular Neuroscience Depression BDNF Pro-inflammatory cytokines Antidepressants growth factors stressors |
| title | Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses |
| title_full | Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses |
| title_fullStr | Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses |
| title_full_unstemmed | Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses |
| title_short | Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses |
| title_sort | interplay between pro inflammatory cytokines and growth factors in depressive illnesses |
| topic | Depression BDNF Pro-inflammatory cytokines Antidepressants growth factors stressors |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00068/full |
| work_keys_str_mv | AT marieclaudeeaudet interplaybetweenproinflammatorycytokinesandgrowthfactorsindepressiveillnesses AT hymieeanisman interplaybetweenproinflammatorycytokinesandgrowthfactorsindepressiveillnesses |