Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis

Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis

Abstract The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole circulating blood, necessitating enhanced detection methodologies. This study sought to amplify assay-sensitivity by employing diag...

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Bibliographic Details
Main Authors: Nikolas H. Stoecklein, Georg Fluegen, Rosa Guglielmi, Rui P.L. Neves, Thilo Hackert, Emrullah Birgin, Stefan A. Cieslik, Monica Sudarsanam, Christiane Driemel, Guus van Dalum, André Franken, Dieter Niederacher, Hans Neubauer, Tanja Fehm, Jutta M. Rox, Petra Böhme, Lena Häberle, Wolfgang Göring, Irene Esposito, Stefan A. Topp, Frank A.W. Coumans, Jürgen Weitz, Wolfram T. Knoefel, Johannes C. Fischer, Ulrich Bork, Nuh N. Rahbari
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Cancer
Subjects:
Pancreatic ductal adenocarcinoma
PDAC
Circulating tumor cells
CTCs
High-blood volume analysis
Liquid biopsy
Online Access:https://doi.org/10.1186/s12943-023-01880-1

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