Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study
Background and aims: The high prevalence of prediabetes and diabetes mellitus and its secondary complications in Saudi Arabia is a major healthcare concern. Evidence suggests that despite evidence-based efficacy and safety, metformin is underutilized in prediabetic obese patients. Thus, the aim of t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423001895 |
| _version_ | 1797689493885550592 |
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| author | Osamah M. Alfayez Sumaia N. Alfuraih Basmah I. Alsalamah Hadeel M. Almendeel Omar S. Alkhezi Saad Alharbi Naief A. Alwohaibi Muhammad Kamran Rasheed |
| author_facet | Osamah M. Alfayez Sumaia N. Alfuraih Basmah I. Alsalamah Hadeel M. Almendeel Omar S. Alkhezi Saad Alharbi Naief A. Alwohaibi Muhammad Kamran Rasheed |
| author_sort | Osamah M. Alfayez |
| collection | DOAJ |
| description | Background and aims: The high prevalence of prediabetes and diabetes mellitus and its secondary complications in Saudi Arabia is a major healthcare concern. Evidence suggests that despite evidence-based efficacy and safety, metformin is underutilized in prediabetic obese patients. Thus, the aim of this study was to investigate the use of metformin in prediabetic obese patients in the Qassim region of Saudi Arabia. Methods: Prediabetic patients' electronic health records were accessed and screened from 2017 to 2021. The inclusion criteria were patients with obesity (BMI ≥ 35) diagnosed with prediabetes, and who received metformin. Patients with chronic kidney disease and those using metformin for other diseases were excluded. The first major endpoint of this study was the rate of metformin use among obese, prediabetic individuals. The second major endpoint was the factors associated with metformin prescribing in our cohort. Descriptive statistics were used to report the primary and secondary outcomes. Data are presented as percentages, means, standard deviations (SDs), medians, and interquartile ranges, as appropriate. All analyses were conducted using Stata version 16.1. Results: A total of 304 prediabetic patients were included in this study after screening the records of 1,789 patients. The average age was found to be 40, and the majority were female (72%). The average BMI was found to be 39.4 kg/m2, while the average HbA1c was 5.8%. In the entire sample, only 25 (8.22%) obese patients received metformin for diabetes prevention. Among obese patients with a BMI ≥ 30, 19 patients (8.7%) received metformin. Metformin users had higher odds of being on statins (OR 2.72, 95% CI 1.01 to 7.36; p = 0.049). Conclusion: According to the study, metformin is not frequently prescribed to prediabetic obese individuals in the Qassim region of Saudi Arabia. This prevention strategy is a missed opportunity in the management of prediabetes in high-risk patients. Future studies are needed to investigate the root causes of the underuse of metformin and potential interventions to promote evidence-based practice in Saudi Arabia. |
| first_indexed | 2024-03-12T01:47:22Z |
| format | Article |
| id | doaj.art-5c188a43770645248280ad4a9f948391 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-12T01:47:22Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-5c188a43770645248280ad4a9f9483912023-09-09T04:54:38ZengElsevierSaudi Pharmaceutical Journal1319-01642023-09-01319101694Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational studyOsamah M. Alfayez0Sumaia N. Alfuraih1Basmah I. Alsalamah2Hadeel M. Almendeel3Omar S. Alkhezi4Saad Alharbi5Naief A. Alwohaibi6Muhammad Kamran Rasheed7Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia; Corresponding author at: Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi Arabia.College of Pharmacy, Qassim University, Qassim, Saudi ArabiaCollege of Pharmacy, Qassim University, Qassim, Saudi ArabiaCollege of Pharmacy, Qassim University, Qassim, Saudi ArabiaDepartment of Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia; Department of Pharmacy Services, Brigham and Women’s Hospital, Boston, MA, USAPharmacy services, Buraidah central hospital, Qassim, Saudi ArabaiDepartment of Pharmacy, King Saud Hospital, Qassim, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, Saudi ArabiaBackground and aims: The high prevalence of prediabetes and diabetes mellitus and its secondary complications in Saudi Arabia is a major healthcare concern. Evidence suggests that despite evidence-based efficacy and safety, metformin is underutilized in prediabetic obese patients. Thus, the aim of this study was to investigate the use of metformin in prediabetic obese patients in the Qassim region of Saudi Arabia. Methods: Prediabetic patients' electronic health records were accessed and screened from 2017 to 2021. The inclusion criteria were patients with obesity (BMI ≥ 35) diagnosed with prediabetes, and who received metformin. Patients with chronic kidney disease and those using metformin for other diseases were excluded. The first major endpoint of this study was the rate of metformin use among obese, prediabetic individuals. The second major endpoint was the factors associated with metformin prescribing in our cohort. Descriptive statistics were used to report the primary and secondary outcomes. Data are presented as percentages, means, standard deviations (SDs), medians, and interquartile ranges, as appropriate. All analyses were conducted using Stata version 16.1. Results: A total of 304 prediabetic patients were included in this study after screening the records of 1,789 patients. The average age was found to be 40, and the majority were female (72%). The average BMI was found to be 39.4 kg/m2, while the average HbA1c was 5.8%. In the entire sample, only 25 (8.22%) obese patients received metformin for diabetes prevention. Among obese patients with a BMI ≥ 30, 19 patients (8.7%) received metformin. Metformin users had higher odds of being on statins (OR 2.72, 95% CI 1.01 to 7.36; p = 0.049). Conclusion: According to the study, metformin is not frequently prescribed to prediabetic obese individuals in the Qassim region of Saudi Arabia. This prevention strategy is a missed opportunity in the management of prediabetes in high-risk patients. Future studies are needed to investigate the root causes of the underuse of metformin and potential interventions to promote evidence-based practice in Saudi Arabia.http://www.sciencedirect.com/science/article/pii/S1319016423001895MetforminPrediabetesDiabetes mellitusPrevalenceObesityPublic health |
| spellingShingle | Osamah M. Alfayez Sumaia N. Alfuraih Basmah I. Alsalamah Hadeel M. Almendeel Omar S. Alkhezi Saad Alharbi Naief A. Alwohaibi Muhammad Kamran Rasheed Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study Saudi Pharmaceutical Journal Metformin Prediabetes Diabetes mellitus Prevalence Obesity Public health |
| title | Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study |
| title_full | Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study |
| title_fullStr | Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study |
| title_full_unstemmed | Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study |
| title_short | Metformin use among obese patients with prediabetes in Qassim, Saudi Arabia: An observational study |
| title_sort | metformin use among obese patients with prediabetes in qassim saudi arabia an observational study |
| topic | Metformin Prediabetes Diabetes mellitus Prevalence Obesity Public health |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423001895 |
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