Aetiology of Primary Spontaneous Pneumothorax
Air in the pleural cavity is termed pneumothorax. When this occurs in the absence of trauma or medical intervention, it is called spontaneous pneumothorax. Primary spontaneous pneumothorax typically occurs in young patients without known lung disease. However, the idea that these patients have “norm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/3/490 |
| _version_ | 1797487029379923968 |
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| author | Rob Hallifax |
| author_facet | Rob Hallifax |
| author_sort | Rob Hallifax |
| collection | DOAJ |
| description | Air in the pleural cavity is termed pneumothorax. When this occurs in the absence of trauma or medical intervention, it is called spontaneous pneumothorax. Primary spontaneous pneumothorax typically occurs in young patients without known lung disease. However, the idea that these patients have “normal” lungs is outdated. This article will review evidence of inflammation and respiratory bronchiolitis on surgical specimens, discuss the identification of emphysema-like change (i.e., blebs and bullae), the concept of pleural porosity and review recent data on the overexpression of matrix metalloproteinases in the lungs of patients who have had pneumothorax. |
| first_indexed | 2024-03-09T23:42:51Z |
| format | Article |
| id | doaj.art-5c1c17d2d4d44d39af5dc7a7d34e744c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:42:51Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5c1c17d2d4d44d39af5dc7a7d34e744c2023-11-23T16:49:11ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111349010.3390/jcm11030490Aetiology of Primary Spontaneous PneumothoraxRob Hallifax0Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, NHS Trust, Oxford OX3 7LJ, UKAir in the pleural cavity is termed pneumothorax. When this occurs in the absence of trauma or medical intervention, it is called spontaneous pneumothorax. Primary spontaneous pneumothorax typically occurs in young patients without known lung disease. However, the idea that these patients have “normal” lungs is outdated. This article will review evidence of inflammation and respiratory bronchiolitis on surgical specimens, discuss the identification of emphysema-like change (i.e., blebs and bullae), the concept of pleural porosity and review recent data on the overexpression of matrix metalloproteinases in the lungs of patients who have had pneumothorax.https://www.mdpi.com/2077-0383/11/3/490pneumothoraxspontaneousaetiologyblebbullaemetalloproteinase |
| spellingShingle | Rob Hallifax Aetiology of Primary Spontaneous Pneumothorax Journal of Clinical Medicine pneumothorax spontaneous aetiology bleb bullae metalloproteinase |
| title | Aetiology of Primary Spontaneous Pneumothorax |
| title_full | Aetiology of Primary Spontaneous Pneumothorax |
| title_fullStr | Aetiology of Primary Spontaneous Pneumothorax |
| title_full_unstemmed | Aetiology of Primary Spontaneous Pneumothorax |
| title_short | Aetiology of Primary Spontaneous Pneumothorax |
| title_sort | aetiology of primary spontaneous pneumothorax |
| topic | pneumothorax spontaneous aetiology bleb bullae metalloproteinase |
| url | https://www.mdpi.com/2077-0383/11/3/490 |
| work_keys_str_mv | AT robhallifax aetiologyofprimaryspontaneouspneumothorax |