Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features
Cutaneous sebaceous carcinoma can be classified into periocular and extraocular and can occur as part of Muir Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the Literature, dermoscopy is characterized in most cases by yel...
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| Format: | Article |
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PAGEPress Publications
2023-09-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/9832 |
| _version_ | 1797687115126931456 |
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| author | Francesco Savoia Matelda Medri Davide Melandri Lucia Domeniconi Emilia Crisanti Andrea Sechi Ignazio Stanganelli |
| author_facet | Francesco Savoia Matelda Medri Davide Melandri Lucia Domeniconi Emilia Crisanti Andrea Sechi Ignazio Stanganelli |
| author_sort | Francesco Savoia |
| collection | DOAJ |
| description |
Cutaneous sebaceous carcinoma can be classified into periocular and extraocular and can occur as part of Muir Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the Literature, dermoscopy is characterized in most cases by yellow color, polymorphic vessels and ulceration. We performed a review of the Literature and we found 14 papers describing the dermoscopic features of 33 sebaceous carcinomas, to which we added a case that we have recently observed. Compared to the data of the Literature and in particular to the latest published reviews, we found that milky-red areas are frequently observed in CSC (47% of the cases) and can be added to the main dermoscopic features for the diagnosis. Histology showed, in our case, some features that were consistent with a cutaneous sebaceous carcinoma with a secretory pattern, and other features that were instead consistent with a non-secretory pattern. This was probably due to the fact that the lesion we observed was a moderately differentiated and not well-differentiated cutaneous sebaceous carcinoma. The presence of a cutaneous sebaceous carcinoma should always alert the clinician on the possible association with Muir-Torre syndrome and immunohistochemistry for mismatch repair genes defects can help in the diagnostic pathway.
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| first_indexed | 2024-03-12T01:14:36Z |
| format | Article |
| id | doaj.art-5c1ec5f4841a40259cf37c0c1ecde0cd |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-03-12T01:14:36Z |
| publishDate | 2023-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-5c1ec5f4841a40259cf37c0c1ecde0cd2023-09-13T18:25:52ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062023-09-0110.4081/dr.2023.9832Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic featuresFrancesco Savoia0Matelda Medri1Davide Melandri2Lucia Domeniconi3Emilia Crisanti4Andrea Sechi5Ignazio Stanganelli6Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola (FC)Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola (FC)Dermatology Unit, Bufalini Hospital, AUSL della Romagna, Cesena (FC); Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of BolognaPathologic Anatomy, AUSL della Romagna, RavennaPathologic Anatomy, AUSL della Romagna, RavennaDermatology Unit, San Bortolo Hospital, VicenzaDermatology Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma Cutaneous sebaceous carcinoma can be classified into periocular and extraocular and can occur as part of Muir Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the Literature, dermoscopy is characterized in most cases by yellow color, polymorphic vessels and ulceration. We performed a review of the Literature and we found 14 papers describing the dermoscopic features of 33 sebaceous carcinomas, to which we added a case that we have recently observed. Compared to the data of the Literature and in particular to the latest published reviews, we found that milky-red areas are frequently observed in CSC (47% of the cases) and can be added to the main dermoscopic features for the diagnosis. Histology showed, in our case, some features that were consistent with a cutaneous sebaceous carcinoma with a secretory pattern, and other features that were instead consistent with a non-secretory pattern. This was probably due to the fact that the lesion we observed was a moderately differentiated and not well-differentiated cutaneous sebaceous carcinoma. The presence of a cutaneous sebaceous carcinoma should always alert the clinician on the possible association with Muir-Torre syndrome and immunohistochemistry for mismatch repair genes defects can help in the diagnostic pathway. https://www.pagepress.org/journals/index.php/dr/article/view/9832Cutaneous sebaceous carcinomaMuir-Torre syndromehereditary nonpolyposis colorectal cancer syndromedermoscopy |
| spellingShingle | Francesco Savoia Matelda Medri Davide Melandri Lucia Domeniconi Emilia Crisanti Andrea Sechi Ignazio Stanganelli Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features Dermatology Reports Cutaneous sebaceous carcinoma Muir-Torre syndrome hereditary nonpolyposis colorectal cancer syndrome dermoscopy |
| title | Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features |
| title_full | Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features |
| title_fullStr | Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features |
| title_full_unstemmed | Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features |
| title_short | Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features |
| title_sort | extraocular cutaneous sebaceous carcinoma in a patient with muir torre syndrome special emphasis on histologic and dermoscopic features |
| topic | Cutaneous sebaceous carcinoma Muir-Torre syndrome hereditary nonpolyposis colorectal cancer syndrome dermoscopy |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/9832 |
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