Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot
Background Increased aortic wall stiffness, which even persists after repair, has been reported in patients with tetralogy of Fallot (TOF). We aimed to observe the distensibility of the ascending aorta and descending aorta in fetuses with TOF and explore its relation with aortic blood flow volume an...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.028499 |
| _version_ | 1797810183948206080 |
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| author | Dan Zhou Ran Xu Jiawei Zhou Minghui Liu Ganqiong Xu Min Hou Shi Zeng |
| author_facet | Dan Zhou Ran Xu Jiawei Zhou Minghui Liu Ganqiong Xu Min Hou Shi Zeng |
| author_sort | Dan Zhou |
| collection | DOAJ |
| description | Background Increased aortic wall stiffness, which even persists after repair, has been reported in patients with tetralogy of Fallot (TOF). We aimed to observe the distensibility of the ascending aorta and descending aorta in fetuses with TOF and explore its relation with aortic blood flow volume and aortic and pulmonary annular size. Methods and Results Twenty‐three fetuses with TOF and 23 gestational age–matched normal fetuses were included in this prospective cross‐sectional study. The distensibilities of the ascending aorta and descending aorta were assessed by aortic strain (AS), which was defined as follows: 100×(maximum internal diameter in the systolic phase–minimum internal diameter in the diastolic phase)/minimum internal diameter in the diastolic phase. The maximum internal diameter in the systolic phase and minimum internal diameter in the diastolic phase of the ascending aorta and descending aorta were measured by M‐mode echocardiography. Associations between AS and aortic blood flow volume and aortic and pulmonary valve diameters were assessed in both groups. AS of the ascending aorta in TOF group was lower than that in controls (20.48%±4.19% versus 28.17%±4.54%; P<0.001), whereas there was no significant difference in the descending aorta. The multivariate regression model demonstrated that AS was significantly related to aortic valve size (P=0.014) and aortic blood flow volume (P=0.022) in fetuses with TOF, whereas only aortic blood flow volume was significantly correlated with AS in the control group (P=0.01). No significant association was found between AS and pulmonary valve size. Conclusions Impaired distensibility of proximal aorta was observed in fetuses with TOF. Both intrinsic abnormalities of the aortic wall and aortic volume overload probably play roles in the altered aortic distensibility. |
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| format | Article |
| id | doaj.art-5c1eeed7fb124a7c81a011328dfd603f |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-13T07:04:24Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-5c1eeed7fb124a7c81a011328dfd603f2023-06-06T12:15:47ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-06-01121110.1161/JAHA.122.028499Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of FallotDan Zhou0Ran Xu1Jiawei Zhou2Minghui Liu3Ganqiong Xu4Min Hou5Shi Zeng6Department of Ultrasound Diagnosis The Second Xiangya Hospital of Central South University Changsha ChinaDepartment of Urology The Second Xiangya Hospital, Central South University Changsha ChinaDepartment of Ultrasound Diagnosis The Second Xiangya Hospital of Central South University Changsha ChinaDepartment of Ultrasound Diagnosis The Second Xiangya Hospital of Central South University Changsha ChinaDepartment of Ultrasound Diagnosis The Second Xiangya Hospital of Central South University Changsha ChinaDepartment of Cardiovascular Surgery The Second Xiangya Hospital, Central South University Changsha ChinaDepartment of Ultrasound Diagnosis The Second Xiangya Hospital of Central South University Changsha ChinaBackground Increased aortic wall stiffness, which even persists after repair, has been reported in patients with tetralogy of Fallot (TOF). We aimed to observe the distensibility of the ascending aorta and descending aorta in fetuses with TOF and explore its relation with aortic blood flow volume and aortic and pulmonary annular size. Methods and Results Twenty‐three fetuses with TOF and 23 gestational age–matched normal fetuses were included in this prospective cross‐sectional study. The distensibilities of the ascending aorta and descending aorta were assessed by aortic strain (AS), which was defined as follows: 100×(maximum internal diameter in the systolic phase–minimum internal diameter in the diastolic phase)/minimum internal diameter in the diastolic phase. The maximum internal diameter in the systolic phase and minimum internal diameter in the diastolic phase of the ascending aorta and descending aorta were measured by M‐mode echocardiography. Associations between AS and aortic blood flow volume and aortic and pulmonary valve diameters were assessed in both groups. AS of the ascending aorta in TOF group was lower than that in controls (20.48%±4.19% versus 28.17%±4.54%; P<0.001), whereas there was no significant difference in the descending aorta. The multivariate regression model demonstrated that AS was significantly related to aortic valve size (P=0.014) and aortic blood flow volume (P=0.022) in fetuses with TOF, whereas only aortic blood flow volume was significantly correlated with AS in the control group (P=0.01). No significant association was found between AS and pulmonary valve size. Conclusions Impaired distensibility of proximal aorta was observed in fetuses with TOF. Both intrinsic abnormalities of the aortic wall and aortic volume overload probably play roles in the altered aortic distensibility.https://www.ahajournals.org/doi/10.1161/JAHA.122.028499aortic distensibilityaortic strainechocardiographytetralogy of Fallot |
| spellingShingle | Dan Zhou Ran Xu Jiawei Zhou Minghui Liu Ganqiong Xu Min Hou Shi Zeng Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aortic distensibility aortic strain echocardiography tetralogy of Fallot |
| title | Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot |
| title_full | Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot |
| title_fullStr | Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot |
| title_full_unstemmed | Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot |
| title_short | Impaired Distensibility of the Proximal Aorta in Fetuses With Tetralogy of Fallot |
| title_sort | impaired distensibility of the proximal aorta in fetuses with tetralogy of fallot |
| topic | aortic distensibility aortic strain echocardiography tetralogy of Fallot |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.028499 |
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