Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions

Continuous-flow Heck synthesis of 4-methoxybiphenyl and methyl 4-methoxycinnamate in supercritical carbon dioxide expanded solvent solutions

The palladium metal catalysed Heck reaction of 4-iodoanisole with styrene or methyl acrylate has been studied in a continuous plug flow reactor (PFR) using supercritical carbon dioxide (scCO2) as the solvent, with THF and methanol as modifiers. The catalyst was 2% palladium on silica and the base wa...

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Bibliographic Details
Main Authors: Phei Li Lau, Ray W. K. Allen, Peter Styring
Format: Article
Language:English
Published: Beilstein-Institut 2013-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
continuous flow
flow chemistry
Heck
palladium
supercritical carbon dioxide
Online Access:https://doi.org/10.3762/bjoc.9.325

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