Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis.
OBJECTIVE: Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the associatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3962346?pdf=render |
| _version_ | 1819226926103920640 |
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| author | Mengmeng Zhao Yangwu Ren Li Shen Yue Zhang Baosen Zhou |
| author_facet | Mengmeng Zhao Yangwu Ren Li Shen Yue Zhang Baosen Zhou |
| author_sort | Mengmeng Zhao |
| collection | DOAJ |
| description | OBJECTIVE: Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the association, a meta-analysis was performed. METHODS: We searched Pubmed, MedLine and EmBase database to selected eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated using fixed effects model or random effects model to assess the association between MTHFR polymorphisms and NSCL/P in both Asian children and mothers. RESULTS: Finally, nine case-control studies were included. Overall, the MTHFR C677T polymorphism and NSCL/P showed pooled ORs (95%CI) of 1.41(1.23-1.61) in Asian children, and 1.70(1.19-2.42) in Asian mothers. Subgroup analyses by geographical locations further identified the association in Eastern Asian children, Western/Central Asian children and mothers, but not in Eastern Asian mothers. However, no significant relationship between MTHFR A1298C polymorphism and NSCL/P was found in this meta-analysis. CONCLUSIONS: The MTHFR 677T allele was associated with an increased risk of NSCL/P in Asian populations. |
| first_indexed | 2024-12-23T10:33:15Z |
| format | Article |
| id | doaj.art-5c2025043174493d943b53d0ad6fc344 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T10:33:15Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5c2025043174493d943b53d0ad6fc3442022-12-21T17:50:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8824210.1371/journal.pone.0088242Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis.Mengmeng ZhaoYangwu RenLi ShenYue ZhangBaosen ZhouOBJECTIVE: Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the association, a meta-analysis was performed. METHODS: We searched Pubmed, MedLine and EmBase database to selected eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated using fixed effects model or random effects model to assess the association between MTHFR polymorphisms and NSCL/P in both Asian children and mothers. RESULTS: Finally, nine case-control studies were included. Overall, the MTHFR C677T polymorphism and NSCL/P showed pooled ORs (95%CI) of 1.41(1.23-1.61) in Asian children, and 1.70(1.19-2.42) in Asian mothers. Subgroup analyses by geographical locations further identified the association in Eastern Asian children, Western/Central Asian children and mothers, but not in Eastern Asian mothers. However, no significant relationship between MTHFR A1298C polymorphism and NSCL/P was found in this meta-analysis. CONCLUSIONS: The MTHFR 677T allele was associated with an increased risk of NSCL/P in Asian populations.http://europepmc.org/articles/PMC3962346?pdf=render |
| spellingShingle | Mengmeng Zhao Yangwu Ren Li Shen Yue Zhang Baosen Zhou Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. PLoS ONE |
| title | Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. |
| title_full | Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. |
| title_fullStr | Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. |
| title_full_unstemmed | Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. |
| title_short | Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis. |
| title_sort | association between mthfr c677t and a1298c polymorphisms and nscl p risk in asians a meta analysis |
| url | http://europepmc.org/articles/PMC3962346?pdf=render |
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