Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones

Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones

The asymmetric rhodium-catalysed 1,4-addition of alkenylzirconium reagents to 2-cyclohexenone can be useful in the synthesis of 3-alkenyl-2-methylcyclohexanones, provided that formaldehyde is used in trapping the intermediate zirconium enolates. In this manner a four-step sequence leading to the two...

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Bibliographic Details
Main Authors:	Pierre J. De Clercq, Freek A. Vrielynck
Format:	Article
Language:	English
Published:	MDPI AG 2007-02-01
Series:	Molecules
Subjects:	Enantioselective 1 4-addition zirconium O-enolate trapping 2-cyclo-hexenone.
Online Access:	http://www.mdpi.com/1420-3049/12/2/237/

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