The roles and applications of neural stem cells in spinal cord injury repair
Spinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.966866/full |
| _version_ | 1828354014193909760 |
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| author | Wen Guo Xindan Zhang Jiliang Zhai Jiajia Xue |
| author_facet | Wen Guo Xindan Zhang Jiliang Zhai Jiajia Xue |
| author_sort | Wen Guo |
| collection | DOAJ |
| description | Spinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and neuroglial lineages. This feature makes NSCs suitable candidates for regenerating injured spinal cords. Many studies have revealed the therapeutic potential of NSCs. In this review, we discuss from an integrated view how NSCs can help SCI repair. We will discuss the sources and therapeutic potential of NSCs, as well as representative pre-clinical studies and clinical trials of NSC-based therapies for SCI repair. |
| first_indexed | 2024-04-14T02:17:40Z |
| format | Article |
| id | doaj.art-5c21613e7aa9496ea3bd34728cbc5ae2 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-14T02:17:40Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5c21613e7aa9496ea3bd34728cbc5ae22022-12-22T02:18:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.966866966866The roles and applications of neural stem cells in spinal cord injury repairWen Guo0Xindan Zhang1Jiliang Zhai2Jiajia Xue3Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaBeijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, ChinaDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Beijing, ChinaBeijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, ChinaSpinal cord injury (SCI), which has no current cure, places a severe burden on patients. Stem cell-based therapies are considered promising in attempts to repair injured spinal cords; such options include neural stem cells (NSCs). NSCs are multipotent stem cells that differentiate into neuronal and neuroglial lineages. This feature makes NSCs suitable candidates for regenerating injured spinal cords. Many studies have revealed the therapeutic potential of NSCs. In this review, we discuss from an integrated view how NSCs can help SCI repair. We will discuss the sources and therapeutic potential of NSCs, as well as representative pre-clinical studies and clinical trials of NSC-based therapies for SCI repair.https://www.frontiersin.org/articles/10.3389/fbioe.2022.966866/fullneural stem cellspinal cord injuryrepairreviewapplication |
| spellingShingle | Wen Guo Xindan Zhang Jiliang Zhai Jiajia Xue The roles and applications of neural stem cells in spinal cord injury repair Frontiers in Bioengineering and Biotechnology neural stem cell spinal cord injury repair review application |
| title | The roles and applications of neural stem cells in spinal cord injury repair |
| title_full | The roles and applications of neural stem cells in spinal cord injury repair |
| title_fullStr | The roles and applications of neural stem cells in spinal cord injury repair |
| title_full_unstemmed | The roles and applications of neural stem cells in spinal cord injury repair |
| title_short | The roles and applications of neural stem cells in spinal cord injury repair |
| title_sort | roles and applications of neural stem cells in spinal cord injury repair |
| topic | neural stem cell spinal cord injury repair review application |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.966866/full |
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