SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
Abstract Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-020-4924-6 |
| _version_ | 1818452765651763200 |
|---|---|
| author | Valeria Salinas Juana Villarroel Hernán Silva Luisa Herrera Sonia Jerez Alejandra Zazueta Cristián Montes Rodrigo Nieto M. Leonor Bustamante |
| author_facet | Valeria Salinas Juana Villarroel Hernán Silva Luisa Herrera Sonia Jerez Alejandra Zazueta Cristián Montes Rodrigo Nieto M. Leonor Bustamante |
| author_sort | Valeria Salinas |
| collection | DOAJ |
| description | Abstract Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD. |
| first_indexed | 2024-12-14T21:28:18Z |
| format | Article |
| id | doaj.art-5c228959da0e447095bddf39762facaf |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-14T21:28:18Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-5c228959da0e447095bddf39762facaf2022-12-21T22:46:45ZengBMCBMC Research Notes1756-05002020-02-011311510.1186/s13104-020-4924-6SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorderValeria Salinas0Juana Villarroel1Hernán Silva2Luisa Herrera3Sonia Jerez4Alejandra Zazueta5Cristián Montes6Rodrigo Nieto7M. Leonor Bustamante8Neurogenetics Clinic and Laboratory, University Neurology Center and Neurology Section, J.M. Ramos Mejía, Hospital, Faculty of Medicine, Universidad de Buenos AiresUniversity Psychiatric Clinic, Clinical Hospital, Universidad de ChileUniversity Psychiatric Clinic, Clinical Hospital, Universidad de ChileHuman Genetics Program, Biomedical Sciences Institute, Faculty of Medicine, Universidad de ChileUniversity Psychiatric Clinic, Clinical Hospital, Universidad de ChileProgram in Sciences and Engineering for Health, Universidad de ValparaísoUniversity Psychiatric Clinic, Clinical Hospital, Universidad de ChileUniversity Psychiatric Clinic, Clinical Hospital, Universidad de ChileDepartment of Psychiatry and Mental Health, North Division, Faculty of Medicine, Universidad de ChileAbstract Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.https://doi.org/10.1186/s13104-020-4924-6GeneticsPersonalityFive-factor modelGene interaction5HTTLPR |
| spellingShingle | Valeria Salinas Juana Villarroel Hernán Silva Luisa Herrera Sonia Jerez Alejandra Zazueta Cristián Montes Rodrigo Nieto M. Leonor Bustamante SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder BMC Research Notes Genetics Personality Five-factor model Gene interaction 5HTTLPR |
| title | SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder |
| title_full | SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder |
| title_fullStr | SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder |
| title_full_unstemmed | SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder |
| title_short | SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder |
| title_sort | sert and bdnf polymorphisms interplay on neuroticism in borderline personality disorder |
| topic | Genetics Personality Five-factor model Gene interaction 5HTTLPR |
| url | https://doi.org/10.1186/s13104-020-4924-6 |
| work_keys_str_mv | AT valeriasalinas sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT juanavillarroel sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT hernansilva sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT luisaherrera sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT soniajerez sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT alejandrazazueta sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT cristianmontes sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT rodrigonieto sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder AT mleonorbustamante sertandbdnfpolymorphismsinterplayonneuroticisminborderlinepersonalitydisorder |