Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-05-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/15/6/150 |
| _version_ | 1828364823649320960 |
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| author | Sanjay Campbell JeAnn Murray Rupika Delgoda Winklet Gallimore |
| author_facet | Sanjay Campbell JeAnn Murray Rupika Delgoda Winklet Gallimore |
| author_sort | Sanjay Campbell |
| collection | DOAJ |
| description | The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1–3) displayed moderate, concentration dependent, cytotoxicity. |
| first_indexed | 2024-04-14T05:22:27Z |
| format | Article |
| id | doaj.art-5c24c10666744377a0af0a8b088cd7a3 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T05:22:27Z |
| publishDate | 2017-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5c24c10666744377a0af0a8b088cd7a32022-12-22T02:10:08ZengMDPI AGMarine Drugs1660-33972017-05-0115615010.3390/md15060150md15060150Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornisSanjay Campbell0JeAnn Murray1Rupika Delgoda2Winklet Gallimore3Department of Chemistry, University of the West Indies, Mona Campus, St. Andrew JMAAW15, JamaicaNatural Products Institute, University of the West Indies, Mona Campus, St. Andrew JMAAW15, JamaicaNatural Products Institute, University of the West Indies, Mona Campus, St. Andrew JMAAW15, JamaicaDepartment of Chemistry, University of the West Indies, Mona Campus, St. Andrew JMAAW15, JamaicaThe chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1–3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1–3) displayed moderate, concentration dependent, cytotoxicity.http://www.mdpi.com/1660-3397/15/6/150dolastanediterpenesCanistrocarpus cervicornis |
| spellingShingle | Sanjay Campbell JeAnn Murray Rupika Delgoda Winklet Gallimore Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis Marine Drugs dolastane diterpenes Canistrocarpus cervicornis |
| title | Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis |
| title_full | Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis |
| title_fullStr | Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis |
| title_full_unstemmed | Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis |
| title_short | Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis |
| title_sort | two new oxodolastane diterpenes from the jamaican macroalga canistrocarpus cervicornis |
| topic | dolastane diterpenes Canistrocarpus cervicornis |
| url | http://www.mdpi.com/1660-3397/15/6/150 |
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