Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress
This study investigated the effects of vitamin E and selenium yeast on the cognitive performance of pups whose dams were subjected to prenatal noise stress (PNS). Twenty-five pregnant Wistar rats were divided into five groups, group 1 (negative control; received 1 mL/kg of distilled water without no...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Scientific African |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468227623002442 |
| _version_ | 1797676219852914688 |
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| author | Okwute Michael Ochayi Dike C. Obalum A Ngabea Murtala Lawan Jabba Hamidu Maduka Luke Nweke Innocent Abi Obianuju Ibifuro Ojikah Eghosa Iyare Bond Anyaehie |
| author_facet | Okwute Michael Ochayi Dike C. Obalum A Ngabea Murtala Lawan Jabba Hamidu Maduka Luke Nweke Innocent Abi Obianuju Ibifuro Ojikah Eghosa Iyare Bond Anyaehie |
| author_sort | Okwute Michael Ochayi |
| collection | DOAJ |
| description | This study investigated the effects of vitamin E and selenium yeast on the cognitive performance of pups whose dams were subjected to prenatal noise stress (PNS). Twenty-five pregnant Wistar rats were divided into five groups, group 1 (negative control; received 1 mL/kg of distilled water without noise stress (NS); group 2: (positive control), received 1 mL/kg of distilled water group 3: received vitamin E; 100 mg/kg/day group 4: selenium yeast (0.4 mg/kg/day) and group 5: vitamin E (100 mg/kg/day bw) and selenium yeast (0.4 mg/kg/day). All administrations were done 30 min before the induction of white noise at 100 dB/4 h (0900–1300 h) /day for 15 days. On gestational day 21, five pups (n = 5) were randomly selected from each group. The pups were subjected to cognitive tests using the Y-maze apparatus on days 21 and 22. All experimental animals were sacrificed on day 23 for tissue processing. Data were analyzed using one-way ANOVA and a value of p˂0.05 was considered statistically significant. The serum corticosterone (CORT) levels statistically increased in group 2 (p˂0.001) compared with groups 1, 3, 4 and 5. Brain homogenate showed an increased level of Malondialdehyde (MDA), decreased levels of glutathione reeducates (Gpx), catalase (CAT) and superoxide dismutase (SOD) in group 2 compared to 1. Glial cell activation was prominient in group 2 compared to group 1. Prenatal noise stress-induced cognitive impairments in pups whose dams were exposed to NS, but this impairment was mitigated with the administration of vitamin E, selenium yeast and combined administration of selenium yeast and vitamin E. |
| first_indexed | 2024-03-11T22:25:49Z |
| format | Article |
| id | doaj.art-5c25cb4f2ebd44a790139ae64640e731 |
| institution | Directory Open Access Journal |
| issn | 2468-2276 |
| language | English |
| last_indexed | 2024-03-11T22:25:49Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Scientific African |
| spelling | doaj.art-5c25cb4f2ebd44a790139ae64640e7312023-09-24T05:16:04ZengElsevierScientific African2468-22762023-09-0121e01788Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stressOkwute Michael Ochayi0Dike C. Obalum1A Ngabea Murtala2Lawan Jabba Hamidu3Maduka Luke Nweke4Innocent Abi5Obianuju Ibifuro Ojikah6Eghosa Iyare7Bond Anyaehie8Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, Nigeria; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Enugu State, Nigeria; Correspdonding author at: Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, Nigeria.Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, Nigeria; Department of Medicine, Maitama District Hospital, Abuja, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Enugu State, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Benue State University, Benue State, Makurdi, NigeriaDepartment of Biotechnology, Faculty of Computing and Applied Science, Baze University, Abuja, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Enugu State, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Enugu State, NigeriaThis study investigated the effects of vitamin E and selenium yeast on the cognitive performance of pups whose dams were subjected to prenatal noise stress (PNS). Twenty-five pregnant Wistar rats were divided into five groups, group 1 (negative control; received 1 mL/kg of distilled water without noise stress (NS); group 2: (positive control), received 1 mL/kg of distilled water group 3: received vitamin E; 100 mg/kg/day group 4: selenium yeast (0.4 mg/kg/day) and group 5: vitamin E (100 mg/kg/day bw) and selenium yeast (0.4 mg/kg/day). All administrations were done 30 min before the induction of white noise at 100 dB/4 h (0900–1300 h) /day for 15 days. On gestational day 21, five pups (n = 5) were randomly selected from each group. The pups were subjected to cognitive tests using the Y-maze apparatus on days 21 and 22. All experimental animals were sacrificed on day 23 for tissue processing. Data were analyzed using one-way ANOVA and a value of p˂0.05 was considered statistically significant. The serum corticosterone (CORT) levels statistically increased in group 2 (p˂0.001) compared with groups 1, 3, 4 and 5. Brain homogenate showed an increased level of Malondialdehyde (MDA), decreased levels of glutathione reeducates (Gpx), catalase (CAT) and superoxide dismutase (SOD) in group 2 compared to 1. Glial cell activation was prominient in group 2 compared to group 1. Prenatal noise stress-induced cognitive impairments in pups whose dams were exposed to NS, but this impairment was mitigated with the administration of vitamin E, selenium yeast and combined administration of selenium yeast and vitamin E.http://www.sciencedirect.com/science/article/pii/S2468227623002442Glial cellsNoisePrenatal stressSelenium yeastVitamin E |
| spellingShingle | Okwute Michael Ochayi Dike C. Obalum A Ngabea Murtala Lawan Jabba Hamidu Maduka Luke Nweke Innocent Abi Obianuju Ibifuro Ojikah Eghosa Iyare Bond Anyaehie Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress Scientific African Glial cells Noise Prenatal stress Selenium yeast Vitamin E |
| title | Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| title_full | Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| title_fullStr | Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| title_full_unstemmed | Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| title_short | Effects of vitamin E and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| title_sort | effects of vitamin e and selenium yeast on cognitive performance of pups whose dams were subjected to prenatal noise stress |
| topic | Glial cells Noise Prenatal stress Selenium yeast Vitamin E |
| url | http://www.sciencedirect.com/science/article/pii/S2468227623002442 |
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