Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
Plain English summary Osteosarcoma is a devastating condition that is prevalent in the Irish Wolfhound breed. In this study, our aim was to estimate heritability of osteosarcoma in the Irish Wolfhound breed. We undertook a pedigree-based analysis to estimate heritability of osteosarcoma in the Irish...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Canine Medicine and Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40575-021-00109-y |
| _version_ | 1818916420944134144 |
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| author | Mehdi Momen Nyah L. Kohler Emily E. Binversie Mariellen Dentino Susannah J. Sample |
| author_facet | Mehdi Momen Nyah L. Kohler Emily E. Binversie Mariellen Dentino Susannah J. Sample |
| author_sort | Mehdi Momen |
| collection | DOAJ |
| description | Plain English summary Osteosarcoma is a devastating condition that is prevalent in the Irish Wolfhound breed. In this study, our aim was to estimate heritability of osteosarcoma in the Irish Wolfhound breed. We undertook a pedigree-based analysis to estimate heritability of osteosarcoma in the Irish Wolfhound. The pedigree used included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with osteosarcoma and 360 control dogs. We considered dogs to be controls if they were over 10 years of age and were not reported to have developed osteosarcoma. This study found the heritability estimate of osteosarcoma in the Irish Wolfhound to be 0.65. This score means that osteosarcoma in this breed is: 1) highly heritable and 2) a complex trait, which means that both environmental and genetic factors influence disease risk. Overall, our results provide support for further investigation into the genetic variants involved in the development of osteosarcoma in Irish Wolfhounds. |
| first_indexed | 2024-12-20T00:17:54Z |
| format | Article |
| id | doaj.art-5c25e9f18e23457ba9a23eeb9ed0dd39 |
| institution | Directory Open Access Journal |
| issn | 2662-9380 |
| language | English |
| last_indexed | 2024-12-20T00:17:54Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Canine Medicine and Genetics |
| spelling | doaj.art-5c25e9f18e23457ba9a23eeb9ed0dd392022-12-21T20:00:17ZengBMCCanine Medicine and Genetics2662-93802021-10-01811910.1186/s40575-021-00109-yHeritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree informationMehdi Momen0Nyah L. Kohler1Emily E. Binversie2Mariellen Dentino3Susannah J. Sample4Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-MadisonDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-MadisonDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-MadisonIrish Wolfhound FoundationDepartment of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-MadisonPlain English summary Osteosarcoma is a devastating condition that is prevalent in the Irish Wolfhound breed. In this study, our aim was to estimate heritability of osteosarcoma in the Irish Wolfhound breed. We undertook a pedigree-based analysis to estimate heritability of osteosarcoma in the Irish Wolfhound. The pedigree used included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with osteosarcoma and 360 control dogs. We considered dogs to be controls if they were over 10 years of age and were not reported to have developed osteosarcoma. This study found the heritability estimate of osteosarcoma in the Irish Wolfhound to be 0.65. This score means that osteosarcoma in this breed is: 1) highly heritable and 2) a complex trait, which means that both environmental and genetic factors influence disease risk. Overall, our results provide support for further investigation into the genetic variants involved in the development of osteosarcoma in Irish Wolfhounds.https://doi.org/10.1186/s40575-021-00109-yVeterinaryGeneticsIrish wolfhoundOsteosarcomaDogCanine |
| spellingShingle | Mehdi Momen Nyah L. Kohler Emily E. Binversie Mariellen Dentino Susannah J. Sample Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information Canine Medicine and Genetics Veterinary Genetics Irish wolfhound Osteosarcoma Dog Canine |
| title | Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information |
| title_full | Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information |
| title_fullStr | Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information |
| title_full_unstemmed | Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information |
| title_short | Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information |
| title_sort | heritability and genetic variance estimation of osteosarcoma osa in irish wolfhound using deep pedigree information |
| topic | Veterinary Genetics Irish wolfhound Osteosarcoma Dog Canine |
| url | https://doi.org/10.1186/s40575-021-00109-y |
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