Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy
Background Pulmonary endarterectomy (PEA) is the preferred treatment for CTEPH patients which can significantly improve symptoms and pulmonary hemodynamics. Therefore, this retrospective study evaluated the long-term outcomes after pulmonary endarterectomy (PEA) and analyze the predictors of long-te...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-12-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221140882 |
| _version_ | 1811209414289391616 |
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| author | Shuai Sun BS Ji-Feng Li MD, PhD Lin Liu MS Ran Miao MD, PhD Su-Qiao Yang MD, PhD Tu-Guang Kuang MD, PhD Juan-Ni Gong MD, PhD Song Gu MD, PhD Yan Liu MD, PhD Yuan-Hua Yang MD, PhD |
| author_facet | Shuai Sun BS Ji-Feng Li MD, PhD Lin Liu MS Ran Miao MD, PhD Su-Qiao Yang MD, PhD Tu-Guang Kuang MD, PhD Juan-Ni Gong MD, PhD Song Gu MD, PhD Yan Liu MD, PhD Yuan-Hua Yang MD, PhD |
| author_sort | Shuai Sun BS |
| collection | DOAJ |
| description | Background Pulmonary endarterectomy (PEA) is the preferred treatment for CTEPH patients which can significantly improve symptoms and pulmonary hemodynamics. Therefore, this retrospective study evaluated the long-term outcomes after pulmonary endarterectomy (PEA) and analyze the predictors of long-term outcomes for chronic thromboembolic pulmonary hypertension (CTEPH). Methods From 2002–2020, 76 CTEPH patients successfully discharged after PEA in Beijing Chaoyang Hospital were followed-up by scheduled clinical visits or telephone interviews. The follow-up time lasted for 18 years and median time was 7.29 years. Results The survival rate at 1,3,5,10,15 years postoperatively was 100.00%, 97.10%, 95.40%, 89.80% and 82.90%, respectively. Multivariate logistics regression analysis showed that postoperative mPAP (hazard ratio: 1.144; 95%confidence interval: 1.018–1.285; P = 0.023) was associated with a higher risk of late death, right atrium right and left diameters (hazard ratio: 1.113; 95%confidence interval, 1.006–1.231; P = 0.038) were associated with a higher risk of major adverse events. Conclusion Pulmonary endarterectomy is an effective way to treat CTEPH. Long-term outcome is excellent for patients who undergoing pulmonary endarterectomy who survived from peri-operation time. Postoperative mPAP is a significant prognostic factor for long-term death and right atrium right and left diameters is a significant prognostic factor for major adverse events. That shows patients with high postoperative mPAP and right atrium right and left diameter should be followed up closely. |
| first_indexed | 2024-04-12T04:38:51Z |
| format | Article |
| id | doaj.art-5c29538521c24ec6b48a2254f3e27cda |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-12T04:38:51Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-5c29538521c24ec6b48a2254f3e27cda2022-12-22T03:47:43ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-12-012810.1177/10760296221140882Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary EndarterectomyShuai Sun BS0Ji-Feng Li MD, PhD1Lin Liu MS2Ran Miao MD, PhD3Su-Qiao Yang MD, PhD4Tu-Guang Kuang MD, PhD5Juan-Ni Gong MD, PhD6Song Gu MD, PhD7Yan Liu MD, PhD8Yuan-Hua Yang MD, PhD9 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Respiratory Disease, , Beijing, P.R. China, 100069 Department of Cardiac Surgery, Beijing Chao-Yang Hospital, , Beijing, P.R. China, 100020 Department of Cardiac Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P.R. China, 100020 Department of Respiratory Disease, , Beijing, P.R. China, 100069Background Pulmonary endarterectomy (PEA) is the preferred treatment for CTEPH patients which can significantly improve symptoms and pulmonary hemodynamics. Therefore, this retrospective study evaluated the long-term outcomes after pulmonary endarterectomy (PEA) and analyze the predictors of long-term outcomes for chronic thromboembolic pulmonary hypertension (CTEPH). Methods From 2002–2020, 76 CTEPH patients successfully discharged after PEA in Beijing Chaoyang Hospital were followed-up by scheduled clinical visits or telephone interviews. The follow-up time lasted for 18 years and median time was 7.29 years. Results The survival rate at 1,3,5,10,15 years postoperatively was 100.00%, 97.10%, 95.40%, 89.80% and 82.90%, respectively. Multivariate logistics regression analysis showed that postoperative mPAP (hazard ratio: 1.144; 95%confidence interval: 1.018–1.285; P = 0.023) was associated with a higher risk of late death, right atrium right and left diameters (hazard ratio: 1.113; 95%confidence interval, 1.006–1.231; P = 0.038) were associated with a higher risk of major adverse events. Conclusion Pulmonary endarterectomy is an effective way to treat CTEPH. Long-term outcome is excellent for patients who undergoing pulmonary endarterectomy who survived from peri-operation time. Postoperative mPAP is a significant prognostic factor for long-term death and right atrium right and left diameters is a significant prognostic factor for major adverse events. That shows patients with high postoperative mPAP and right atrium right and left diameter should be followed up closely.https://doi.org/10.1177/10760296221140882 |
| spellingShingle | Shuai Sun BS Ji-Feng Li MD, PhD Lin Liu MS Ran Miao MD, PhD Su-Qiao Yang MD, PhD Tu-Guang Kuang MD, PhD Juan-Ni Gong MD, PhD Song Gu MD, PhD Yan Liu MD, PhD Yuan-Hua Yang MD, PhD Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy Clinical and Applied Thrombosis/Hemostasis |
| title | Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy |
| title_full | Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy |
| title_fullStr | Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy |
| title_full_unstemmed | Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy |
| title_short | Long-term Outcomes and Predictors of Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Endarterectomy |
| title_sort | long term outcomes and predictors of chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy |
| url | https://doi.org/10.1177/10760296221140882 |
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