Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy
Background Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein‐losing enteropathy (PLE), but it also allows for localization of protein loss. Hypothesis/Objectives To investigat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-03-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.14673 |
| _version_ | 1811237815007051776 |
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| author | N. Engelmann N. Ondreka K. vonPückler S. Mohrs J. Sicken R. Neiger |
| author_facet | N. Engelmann N. Ondreka K. vonPückler S. Mohrs J. Sicken R. Neiger |
| author_sort | N. Engelmann |
| collection | DOAJ |
| description | Background Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein‐losing enteropathy (PLE), but it also allows for localization of protein loss. Hypothesis/Objectives To investigate the feasibility of 99mTc‐labeled human serum albumin (HSA) scintigraphy in dogs with PLE in comparison with control dogs. Animals A total of 8 clinically healthy control research dogs and 7 client‐owned dogs with gastrointestinal clinical signs and hypoalbuminemia (serum albumin concentration <2.0 g/dL). Methods Prospective case–control study. After IV injection of 400 MBq freshly prepared 99mTc HSA (30 mg/dog), images of the abdomen were obtained 10, 60, 120, and 240 minutes postinjection. Additional images of the salivary and thyroid glands were obtained to rule out free 99mTc. A scan was considered positive for PLE when radiopharmaceutical exudation was detectable in the intestinal tract. Results Only 1 control dog showed exudation of the radiopharmaceutical into the intestinal tract. No free 99mTc was detected in any dog. In dogs with PLE, focal small intestinal and diffuse small intestinal radiopharmaceutical exudation into the bowel was detected in 2 and 3 dogs, respectively, whereas in 2 dogs, there was disagreement about whether radiopharmaceutical exudation was focal or diffuse. Conclusion and Clinical Importance 99mTc‐labeled HSA scintigraphy was feasible to diagnose PLE in dogs. |
| first_indexed | 2024-04-12T12:29:43Z |
| format | Article |
| id | doaj.art-5c2a8305064d41d3a0b1bab9d05b2cfb |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T12:29:43Z |
| publishDate | 2017-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-5c2a8305064d41d3a0b1bab9d05b2cfb2022-12-22T03:33:03ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762017-03-0131236537010.1111/jvim.14673Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing EnteropathyN. Engelmann0N. Ondreka1K. vonPückler2S. Mohrs3J. Sicken4R. Neiger5Small Animal Clinic Justus‐Liebig University of Giessen Giessen GermanySmall Animal Clinic Justus‐Liebig University of Giessen Giessen GermanySmall Animal Clinic Justus‐Liebig University of Giessen Giessen GermanySmall Animal Clinic Justus‐Liebig University of Giessen Giessen GermanySmall Animal Clinic Justus‐Liebig University of Giessen Giessen GermanySmall Animal Clinic Justus‐Liebig University of Giessen Giessen GermanyBackground Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein‐losing enteropathy (PLE), but it also allows for localization of protein loss. Hypothesis/Objectives To investigate the feasibility of 99mTc‐labeled human serum albumin (HSA) scintigraphy in dogs with PLE in comparison with control dogs. Animals A total of 8 clinically healthy control research dogs and 7 client‐owned dogs with gastrointestinal clinical signs and hypoalbuminemia (serum albumin concentration <2.0 g/dL). Methods Prospective case–control study. After IV injection of 400 MBq freshly prepared 99mTc HSA (30 mg/dog), images of the abdomen were obtained 10, 60, 120, and 240 minutes postinjection. Additional images of the salivary and thyroid glands were obtained to rule out free 99mTc. A scan was considered positive for PLE when radiopharmaceutical exudation was detectable in the intestinal tract. Results Only 1 control dog showed exudation of the radiopharmaceutical into the intestinal tract. No free 99mTc was detected in any dog. In dogs with PLE, focal small intestinal and diffuse small intestinal radiopharmaceutical exudation into the bowel was detected in 2 and 3 dogs, respectively, whereas in 2 dogs, there was disagreement about whether radiopharmaceutical exudation was focal or diffuse. Conclusion and Clinical Importance 99mTc‐labeled HSA scintigraphy was feasible to diagnose PLE in dogs.https://doi.org/10.1111/jvim.14673Enteral protein lossChronic enteric diseaseCanineDiagnostic imagingNuclear medicine |
| spellingShingle | N. Engelmann N. Ondreka K. vonPückler S. Mohrs J. Sicken R. Neiger Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy Journal of Veterinary Internal Medicine Enteral protein loss Chronic enteric disease Canine Diagnostic imaging Nuclear medicine |
| title | Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy |
| title_full | Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy |
| title_fullStr | Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy |
| title_full_unstemmed | Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy |
| title_short | Applicability of 99mTc‐Labeled Human Serum Albumin Scintigraphy in Dogs With Protein‐Losing Enteropathy |
| title_sort | applicability of 99mtc labeled human serum albumin scintigraphy in dogs with protein losing enteropathy |
| topic | Enteral protein loss Chronic enteric disease Canine Diagnostic imaging Nuclear medicine |
| url | https://doi.org/10.1111/jvim.14673 |
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