Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.

Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.

DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic contributions of MLH3 and PMS2 in gastrointestinal tumor suppression, we generated...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Peng-Chieh Chen, Mari Kuraguchi, John Velasquez, Yuxun Wang, Kan Yang, Robert Edwards, Dan Gillen, Winfried Edelmann, Raju Kucherlapati, Steven M Lipkin
التنسيق: مقال
اللغة:English
منشور في: Public Library of Science (PLoS) 2008-06-01
سلاسل:PLoS Genetics
الوصول للمادة أونلاين:http://europepmc.org/articles/PMC2410297?pdf=render

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