Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats
Background: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives...
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Society of Diabetic Nephropathy Prevention
2017-10-01
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Series: | Journal of Nephropathology |
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Online Access: | https://nephropathol.com/PDF/jnp-6-338.pdf |
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author | Tahereh Safari Saideh Miri Omid Ghofran Fatemeh Fereidooni Abbass Ali Niazi Hossein Bagheri Mehdi Nematbakhsh |
author_facet | Tahereh Safari Saideh Miri Omid Ghofran Fatemeh Fereidooni Abbass Ali Niazi Hossein Bagheri Mehdi Nematbakhsh |
author_sort | Tahereh Safari |
collection | DOAJ |
description | Background: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives: This study aims to investigate the possibility of any gender difference in response to antioxidant effects vitamins E and C in gentamicin-induced nephrotoxicity. Materials and Methods: Wistar rats were randomly assigned to 6 groups each including both male and female rats. The first and second groups received saline (control group) and almond oil, the third group received gentamicin. The fourth group received a regular dose of gentamicin + vitamin E. Similarly, the fifth group received a regular dose of gentamicin + vitamin C. The sixth group received a dose of gentamicin + vitamin C and E simultaneously constantly. This protocol continued for 9 days. Results: Gentamicin increased significantly urea, creatinine (Cr) and malondialdehyde (MDA), but it decreased superoxidase dismutase (SOD) level (P < 0.05). Treatment with antioxidant vitamins improved urea, creatinine, MDA, and SOD serum level significantly in both genders (P <0.05). Likewise, kidney MDA level enhanced significantly (P <0.05) and treatment with antioxidant vitamins reduced MDA level too (P <0.05). Gentamicin decreased kidney SOD activity in male and female rats (P <0.05). However, treatment with antioxidant vitamins did not improve its level in male rats, while in female rats, vitamins E and C compensated for kidney SOD activity. Conclusions: Antioxidant vitamins modified gentamicin-induced nephrotoxicity in both genders, with some difference in response to vitamins E and C between the genders, that was higher in female rats. |
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issn | 2251-8363 2251-8819 |
language | English |
last_indexed | 2024-04-09T12:57:01Z |
publishDate | 2017-10-01 |
publisher | Society of Diabetic Nephropathy Prevention |
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series | Journal of Nephropathology |
spelling | doaj.art-5c2d885dcd284a69bef5ebee00ba28b82023-05-13T11:31:11ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192017-10-016433834510.15171/jnp.2017.54jnp-20170802232729Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar ratsTahereh Safari0Saideh Miri1Omid Ghofran2Fatemeh Fereidooni3Abbass Ali Niazi4Hossein Bagheri5Mehdi Nematbakhsh6Department of Physiology, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Physiology, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Physiology, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Physiology, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Pathology, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Medical English, Zahedan University of Medical Sciences, IranWater and Electrolytes Research Center & Department of Physiology, Isfahan University of Medical Sciences, Isfahan, IranBackground: Nephrotoxicity is the most recognized side effect of gentamicin. Vitamin E and vitamin C demonstrate their effective role in the prevention of nephrotoxicity. Likewise, previous studies have suggested that women have low risk of end-stage renal disease at premenopausal period. Objectives: This study aims to investigate the possibility of any gender difference in response to antioxidant effects vitamins E and C in gentamicin-induced nephrotoxicity. Materials and Methods: Wistar rats were randomly assigned to 6 groups each including both male and female rats. The first and second groups received saline (control group) and almond oil, the third group received gentamicin. The fourth group received a regular dose of gentamicin + vitamin E. Similarly, the fifth group received a regular dose of gentamicin + vitamin C. The sixth group received a dose of gentamicin + vitamin C and E simultaneously constantly. This protocol continued for 9 days. Results: Gentamicin increased significantly urea, creatinine (Cr) and malondialdehyde (MDA), but it decreased superoxidase dismutase (SOD) level (P < 0.05). Treatment with antioxidant vitamins improved urea, creatinine, MDA, and SOD serum level significantly in both genders (P <0.05). Likewise, kidney MDA level enhanced significantly (P <0.05) and treatment with antioxidant vitamins reduced MDA level too (P <0.05). Gentamicin decreased kidney SOD activity in male and female rats (P <0.05). However, treatment with antioxidant vitamins did not improve its level in male rats, while in female rats, vitamins E and C compensated for kidney SOD activity. Conclusions: Antioxidant vitamins modified gentamicin-induced nephrotoxicity in both genders, with some difference in response to vitamins E and C between the genders, that was higher in female rats.https://nephropathol.com/PDF/jnp-6-338.pdfgentamicinnephrotoxicityvitamin evitamin cgender difference |
spellingShingle | Tahereh Safari Saideh Miri Omid Ghofran Fatemeh Fereidooni Abbass Ali Niazi Hossein Bagheri Mehdi Nematbakhsh Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats Journal of Nephropathology gentamicin nephrotoxicity vitamin e vitamin c gender difference |
title | Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats |
title_full | Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats |
title_fullStr | Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats |
title_full_unstemmed | Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats |
title_short | Gender differences in response to vitamin E and C in gentamicin induced nephrotoxicity in Wistar rats |
title_sort | gender differences in response to vitamin e and c in gentamicin induced nephrotoxicity in wistar rats |
topic | gentamicin nephrotoxicity vitamin e vitamin c gender difference |
url | https://nephropathol.com/PDF/jnp-6-338.pdf |
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