Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?
Colorectal cancer (CRC) is the third most common cause of cancer-related death. Significant improvements in CRC treatment have been made for the last 20 years, on one hand thanks to a better detection, allowing surgical resection of the incriminated area, and on the other hand, thanks to a better kn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/8/1749 |
| _version_ | 1797538606103920640 |
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| author | Lauriane Onfroy-Roy Dimitri Hamel Laurent Malaquin Audrey Ferrand |
| author_facet | Lauriane Onfroy-Roy Dimitri Hamel Laurent Malaquin Audrey Ferrand |
| author_sort | Lauriane Onfroy-Roy |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common cause of cancer-related death. Significant improvements in CRC treatment have been made for the last 20 years, on one hand thanks to a better detection, allowing surgical resection of the incriminated area, and on the other hand, thanks to a better knowledge of CRC’s development allowing the improvement of drug strategies. Despite this crucial progress, CRC remains a public health issue. The current model for CRC initiation and progression is based on accumulation of sequential known genetic mutations in the colon epithelial cells’ genome leading to a loss of control over proliferation and survival. However, increasing evidence reveals that CRC initiation is more complex. Indeed, chronic inflammatory contexts, such as inflammatory bowel diseases, have been shown to increase the risk for CRC development in mice and humans. In this manuscript, we review whether colon fibroblasts can go from the main regulators of the ISC homeostasis, regulating not only the renewal process but also the epithelial cells’ differentiation occurring along the colon crypt, to the main player in the initiation of the colorectal cancer process due to chronic inflammation. |
| first_indexed | 2024-03-10T12:33:48Z |
| format | Article |
| id | doaj.art-5c2dbbf1e1e3448db1e22caa37054349 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:33:48Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5c2dbbf1e1e3448db1e22caa370543492023-11-21T14:27:03ZengMDPI AGCancers2072-66942021-04-01138174910.3390/cancers13081749Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?Lauriane Onfroy-Roy0Dimitri Hamel1Laurent Malaquin2Audrey Ferrand3IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, 31024 Toulouse, FranceIRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, 31024 Toulouse, FranceLAAS-CNRS, Université de Toulouse, CNRS, 31024 Toulouse, FranceIRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, 31024 Toulouse, FranceColorectal cancer (CRC) is the third most common cause of cancer-related death. Significant improvements in CRC treatment have been made for the last 20 years, on one hand thanks to a better detection, allowing surgical resection of the incriminated area, and on the other hand, thanks to a better knowledge of CRC’s development allowing the improvement of drug strategies. Despite this crucial progress, CRC remains a public health issue. The current model for CRC initiation and progression is based on accumulation of sequential known genetic mutations in the colon epithelial cells’ genome leading to a loss of control over proliferation and survival. However, increasing evidence reveals that CRC initiation is more complex. Indeed, chronic inflammatory contexts, such as inflammatory bowel diseases, have been shown to increase the risk for CRC development in mice and humans. In this manuscript, we review whether colon fibroblasts can go from the main regulators of the ISC homeostasis, regulating not only the renewal process but also the epithelial cells’ differentiation occurring along the colon crypt, to the main player in the initiation of the colorectal cancer process due to chronic inflammation.https://www.mdpi.com/2072-6694/13/8/1749colonfibroblastsstromacolorectal cancerinflammationintestinal stem cells |
| spellingShingle | Lauriane Onfroy-Roy Dimitri Hamel Laurent Malaquin Audrey Ferrand Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? Cancers colon fibroblasts stroma colorectal cancer inflammation intestinal stem cells |
| title | Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? |
| title_full | Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? |
| title_fullStr | Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? |
| title_full_unstemmed | Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? |
| title_short | Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? |
| title_sort | colon fibroblasts and inflammation sparring partners in colorectal cancer initiation |
| topic | colon fibroblasts stroma colorectal cancer inflammation intestinal stem cells |
| url | https://www.mdpi.com/2072-6694/13/8/1749 |
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