Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial

Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial

Abstract Background This study is in regard to the comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from s...

Full description

Bibliographic Details
Main Authors:	Xiaofang Zhang, Tianlu Wang, Chen Yu Wang, Peng Zhao, Bo Huang, Lei He, Ying Qiu Song
Format:	Article
Language:	English
Published:	BMC 2022-10-01
Series:	Trials
Subjects:	Brain metastases from SCLC Hippocampus protection TOMO Intracranial progression-free survival time Assessment of neurological function
Online Access:	https://doi.org/10.1186/s13063-022-06826-4

Similar Items

PRO: Do We Still Need Whole-Brain Irradiation for Brain Metastases?
by: Ilinca Popp, et al.
Published: (2023-06-01)

Hippocampal sparing in whole-brain radiotherapy for brain metastases: controversy, technology and the future
by: Rui Liu, et al.
Published: (2024-01-01)

Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review
by: Petr Pospisil, et al.
Published: (2024-01-01)

Propensity score-matched analysis comparing hippocampus-avoidance whole-brain radiotherapy plus simultaneous integrated boost with hippocampus‑avoidance whole-brain radiotherapy alone for multiple brain metastases-a retrospective study in multiple institutions
by: Xiaoliang Wang, et al.
Published: (2023-08-01)

Impact of Brain Metastases on Treatment Patterns and Outcomes With First-Line Durvalumab Plus Platinum-Etoposide in Extensive-Stage SCLC (CASPIAN): A Brief Report
by: Yuanbin Chen, MD, PhD, et al.
Published: (2022-06-01)

The First Survival Score for Patients Treated with Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost for Brain Metastases
by: Dirk Rades, et al.
Published: (2023-04-01)

Stereotactic Radiosurgery and Stereotactic Fractionated Radiotherapy in the Management of Brain Metastases
by: Sofian Benkhaled, et al.
Published: (2024-03-01)

Low radiotherapy dose is suitable for brain metastases in SCLC compared with high dose
by: Liming Xu, et al.
Published: (2023-09-01)

Application of piecewise VMAT technique to whole-brain radiotherapy with simultaneous integrated boost for multiple metastases
by: Yuan Xu, et al.
Published: (2022-05-01)

Salvage Treatment for Progressive Brain Metastases in Breast Cancer
by: Mateusz Jacek Spałek, et al.
Published: (2022-02-01)

Re-Irradiation by Stereotactic Radiotherapy of Brain Metastases in the Case of Local Recurrence
by: Ruben Touati, et al.
Published: (2023-02-01)

Immunophenotypic characteristics of brain metastases
by: G. A. Demyashkin, et al.
Published: (2018-12-01)

Immunotherapy in NSCLC Patients with Brain Metastases
by: Silvia Buriolla, et al.
Published: (2022-06-01)

The First Survival Score for Patients Aged ≥80 Years Irradiated for Brain Metastases
by: Dirk Rades, et al.
Published: (2022-09-01)

Strategies to Preserve Cognition in Patients With Brain Metastases: A Review
by: Tyler P. Robin, et al.
Published: (2018-10-01)

Genomic and Transcriptomic Profiling of Brain Metastases
by: Christopher P. Wardell, et al.
Published: (2021-11-01)

Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center
by: Bolanle Adegboyega, et al.
Published: (2023-12-01)

Intracranial Response Rate in Patients with Breast Cancer Brain Metastases after Systemic Therapy
by: Anna Niwinska, et al.
Published: (2022-02-01)

MRI Findings of Brain Metastases in Lung Cancers
by: Ismail Okan Yildirim, et al.
Published: (2014-03-01)

Neurotoxicity-sparing radiotherapy for brain metastases in breast cancer: a narrative review
by: Dagmara Buczek, et al.
Published: (2024-02-01)

Whole-Brain Radiotherapy vs. Localized Radiotherapy after Resection of Brain Metastases in the Era of Targeted Therapy: A Retrospective Study
by: Jaho Koo, et al.
Published: (2021-09-01)

Actual, Personalized Approaches to Preserve Cognitive Functions in Brain Metastases Breast Cancer Patients
by: Monika Konopka-Filippow, et al.
Published: (2022-06-01)

Screening for Brain Metastases in Patients With NSCLC: A Qualitative Study on the Psychologic Impact of Being Diagnosed With Asymptomatic Brain Metastases
by: Janna J.A. O. Schoenmaekers, MD, et al.
Published: (2022-10-01)

Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)
by: Anca-Ligia Grosu, et al.
Published: (2020-06-01)

Current Treatment of Melanoma Brain Metastases
by: Agnieszka Nowacka, et al.
Published: (2023-08-01)

Metabolic Parameters Influence Brain Infarction and Outcome after Resection of Brain Metastases
by: Nicole Lange, et al.
Published: (2020-04-01)

The Prevention of Brain Metastases in Non-Small Cell Lung Cancer by Prophylactic Cranial Irradiation
by: Willem J. A. Witlox, et al.
Published: (2018-07-01)

Different treatment planning strategies for whole-brain radiation therapy with simultaneous integrated boost for multiple brain metastases to protect neurocognitive function with hippocampal sparing
by: Ilknur Harmankaya, et al.
Published: (2022-01-01)

Brain and spinal cord metastases with seminoma: A case report
by: Tetsuya Yumioka, et al.
Published: (2022-11-01)

Evaluation of Whole Brain Radiotherapy among Lung Cancer Patients with Brain Metastases in Relation to Health Care Level and Survival
by: Gabriella Frisk, et al.
Published: (2022-04-01)

Molecular Mechanisms Driving the Formation of Brain Metastases
by: Bethany K. Campbell, et al.
Published: (2022-10-01)

How we treat octogenarians with brain metastases
by: Carsten Nieder, et al.
Published: (2023-08-01)

Melanoma Brain Metastases in the Era of Target Therapies: An Overview
by: Paolo Becco, et al.
Published: (2020-06-01)

Local treatment of breast cancer brain metastases
by: Ana Magličić, et al.
Published: (2022-01-01)

Editorial: Effects of radiation therapies on brain metastases
by: Rupesh Kotecha, et al.
Published: (2023-04-01)

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases
by: Frantisek Siegl, et al.
Published: (2022-07-01)

Stereotactic radiotherapy for brain metastases: predictive factors of radionecrosis
by: Benoît Calderon, et al.
Published: (2023-07-01)

The progress of microenvironment-targeted therapies in brain metastases
by: Lifu Long, et al.
Published: (2023-03-01)

Editorial: Brain and leptomeningeal metastases in lung cancer
by: Tiziana Vavalà, et al.
Published: (2023-01-01)

PD‐L1 inhibitors combined with whole brain radiotherapy in patients with small cell lung cancer brain metastases: Real‐world evidence
by: Litang Huang, et al.
Published: (2024-04-01)