Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder
Abstract Background Obsessive-compulsive disorder (OCD) is related to working memory impairment. Since patients with OCD have difficulty controlling their obsessive thoughts, removal of irrelevant information might be important in the pathophysiology of OCD. However, little is known about brain acti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-05149-1 |
| _version_ | 1797557374287872000 |
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| author | Young Jun Boo Do-Won Kim Jin Young Park Bong Soo Kim Jin Woo Chang Jee In Kang Se Joo Kim |
| author_facet | Young Jun Boo Do-Won Kim Jin Young Park Bong Soo Kim Jin Woo Chang Jee In Kang Se Joo Kim |
| author_sort | Young Jun Boo |
| collection | DOAJ |
| description | Abstract Background Obsessive-compulsive disorder (OCD) is related to working memory impairment. Since patients with OCD have difficulty controlling their obsessive thoughts, removal of irrelevant information might be important in the pathophysiology of OCD. However, little is known about brain activity during the removal of information from working memory in patients with OCD. Our goal was to explore potential deficits in inhibitory function related to working memory processes in patients with OCD. Methods Sixteen OCD patients and 20 healthy controls (HCs) were recruited. We compared in prefrontal alpha and beta band activity derived from magnetoencephalography (MEG) between patients with OCD and HCs during multiple phases of information processing associated with working memory, especially in post-trial period of the visuospatial working memory task (the delayed matching-to‐sample task), which is presumed to be related to the information removal process of working memory. Results Prefrontal post-trial beta power change (presumed to occur at high levels during the post-trial period) exhibited significant reductions in patients with OCD compared to HCs. In addition, the post-trial beta power change was negatively correlated with Obsessive-Compulsive Inventory–Revised total scores in patients with OCD. Conclusions These findings suggest that impairment in the removal of information from working memory might be a key mechanism underlying the inability of OCD patients to rid themselves of their obsessions. |
| first_indexed | 2024-03-10T17:16:12Z |
| format | Article |
| id | doaj.art-5c30ccacbc4e4e11ae54dfa16041d525 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:12Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-5c30ccacbc4e4e11ae54dfa16041d5252023-11-20T10:30:01ZengBMCBMC Psychiatry1471-244X2023-09-0123111210.1186/s12888-023-05149-1Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorderYoung Jun Boo0Do-Won Kim1Jin Young Park2Bong Soo Kim3Jin Woo Chang4Jee In Kang5Se Joo Kim6Department of Psychiatry, Graduate School, Yonsei University College of MedicineDepartment of Biomedical Engineering, College of Engineering Sciences, Chonnam National UniversityDepartment of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of MedicineDepartment of Neurosurgery, Brain Research Institute, Yonsei University College of MedicineDepartment of Neurosurgery, Brain Research Institute, Yonsei University College of MedicineDepartment of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of MedicineDepartment of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of MedicineAbstract Background Obsessive-compulsive disorder (OCD) is related to working memory impairment. Since patients with OCD have difficulty controlling their obsessive thoughts, removal of irrelevant information might be important in the pathophysiology of OCD. However, little is known about brain activity during the removal of information from working memory in patients with OCD. Our goal was to explore potential deficits in inhibitory function related to working memory processes in patients with OCD. Methods Sixteen OCD patients and 20 healthy controls (HCs) were recruited. We compared in prefrontal alpha and beta band activity derived from magnetoencephalography (MEG) between patients with OCD and HCs during multiple phases of information processing associated with working memory, especially in post-trial period of the visuospatial working memory task (the delayed matching-to‐sample task), which is presumed to be related to the information removal process of working memory. Results Prefrontal post-trial beta power change (presumed to occur at high levels during the post-trial period) exhibited significant reductions in patients with OCD compared to HCs. In addition, the post-trial beta power change was negatively correlated with Obsessive-Compulsive Inventory–Revised total scores in patients with OCD. Conclusions These findings suggest that impairment in the removal of information from working memory might be a key mechanism underlying the inability of OCD patients to rid themselves of their obsessions.https://doi.org/10.1186/s12888-023-05149-1Obsessive-compulsive disorderWorking memoryRemoval of informationDelayed matching-to-sample taskBeta oscillationsMagnetoencephalography |
| spellingShingle | Young Jun Boo Do-Won Kim Jin Young Park Bong Soo Kim Jin Woo Chang Jee In Kang Se Joo Kim Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder BMC Psychiatry Obsessive-compulsive disorder Working memory Removal of information Delayed matching-to-sample task Beta oscillations Magnetoencephalography |
| title | Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder |
| title_full | Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder |
| title_fullStr | Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder |
| title_full_unstemmed | Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder |
| title_short | Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder |
| title_sort | altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive compulsive disorder |
| topic | Obsessive-compulsive disorder Working memory Removal of information Delayed matching-to-sample task Beta oscillations Magnetoencephalography |
| url | https://doi.org/10.1186/s12888-023-05149-1 |
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