Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis
The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340915000657 |
| _version_ | 1818109492151189504 |
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| author | Vellaisamy Selvaraj Niraj Nepal Steven Rogers Nandini D.P.K. Manne Ravikumar Arvapalli Kevin M. Rice Shinichi Asano Erin Fankenhanel J.Y. Ma Tolou Shokuhfar Mani Maheshwari Eric R. Blough |
| author_facet | Vellaisamy Selvaraj Niraj Nepal Steven Rogers Nandini D.P.K. Manne Ravikumar Arvapalli Kevin M. Rice Shinichi Asano Erin Fankenhanel J.Y. Ma Tolou Shokuhfar Mani Maheshwari Eric R. Blough |
| author_sort | Vellaisamy Selvaraj |
| collection | DOAJ |
| description | The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay. |
| first_indexed | 2024-12-11T02:32:07Z |
| format | Article |
| id | doaj.art-5c31f91e128441bfb043f5699d68c926 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T02:32:07Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-5c31f91e128441bfb043f5699d68c9262022-12-22T01:23:48ZengElsevierData in Brief2352-34092015-09-014C10511510.1016/j.dib.2015.04.023Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsisVellaisamy Selvaraj0Niraj Nepal1Steven Rogers2Nandini D.P.K. Manne3Ravikumar Arvapalli4Kevin M. Rice5Shinichi Asano6Erin Fankenhanel7J.Y. Ma8Tolou Shokuhfar9Mani Maheshwari10Eric R. Blough11Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USAHealth Effects Laboratory Division, NIOSH, Morgantown, WV, USADepartment of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USACenter for Diagnostic Nanosystems, Marshall University, Huntington, WV, USAThe life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay.http://www.sciencedirect.com/science/article/pii/S2352340915000657SepsisLPSSprague Dawley ratMTTRaw 264.7Cerium oxide nanoparticles |
| spellingShingle | Vellaisamy Selvaraj Niraj Nepal Steven Rogers Nandini D.P.K. Manne Ravikumar Arvapalli Kevin M. Rice Shinichi Asano Erin Fankenhanel J.Y. Ma Tolou Shokuhfar Mani Maheshwari Eric R. Blough Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis Data in Brief Sepsis LPS Sprague Dawley rat MTT Raw 264.7 Cerium oxide nanoparticles |
| title | Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis |
| title_full | Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis |
| title_fullStr | Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis |
| title_full_unstemmed | Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis |
| title_short | Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis |
| title_sort | cerium oxide nanoparticles inhibit lipopolysaccharide induced map kinase nf kb mediated severe sepsis |
| topic | Sepsis LPS Sprague Dawley rat MTT Raw 264.7 Cerium oxide nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2352340915000657 |
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