Personalised diet improve intestine microbiota and metabolism of obese rats
Recent research on human microbiome provide opportunities to develop functional foods of new generation that can regulate intestinal microbiota and the biochemical status of the individual. The aim of the study was to determine the effect of individually designed nutrition on the intestinal microbio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2021-08-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2021/09/Bati_4_21.pdf |
| _version_ | 1797668835510190080 |
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| author | V. V. Bati T. V. Meleshko O. V. Pallah I. P. Zayachuk N. V. Boyko |
| author_facet | V. V. Bati T. V. Meleshko O. V. Pallah I. P. Zayachuk N. V. Boyko |
| author_sort | V. V. Bati |
| collection | DOAJ |
| description | Recent research on human microbiome provide opportunities to develop functional foods of new generation that can regulate intestinal microbiota and the biochemical status of the individual. The aim of the study was to determine the effect of individually designed nutrition on the intestinal microbiota and metabolic parameters of rats. Outbred laboratory rats with obesity were randomly divided into 9 groups (n = 12) depending on the type of food ingredients taken orally for three months. The ratio of the intestinal commensal microorganisms main groups, as well as the lipid profile and the content of glucose, urea, calcium in the serum of animals were determined. It was shown that cholesterol level in the serum was reduced in experimental groups after consumption of lactobacilli suspension, blueberry juice, fermented milk drink based on lactobacilli, fermented milk drink with blueberry juice, sauerkraut. In most cases, the gut microbiome of experimental animals was characterized by a consistently high level of lacto and other beneficial bacteria and decreased amount of opportunistic microorganisms at the end of the experiment compared with animals in the control group. Based on the obtained data, we first proposed the principles of creating functional products by synergistically combining components of edible plants that act as prebiotics and microorganisms that act as probiotics for personalized use, targeted correction of intestinal microbiome and prevention of noncommunicable diseases. |
| first_indexed | 2024-03-11T20:34:16Z |
| format | Article |
| id | doaj.art-5c3221103b5647b1bd12c0b647d07a86 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T20:34:16Z |
| publishDate | 2021-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-5c3221103b5647b1bd12c0b647d07a862023-10-02T07:19:13ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032021-08-01779210.15407/ubj93.04.077Personalised diet improve intestine microbiota and metabolism of obese ratsV. V. Bati0https://orcid.org/0000-0002-7799-9655T. V. Meleshko1https://orcid.org/0000-0003-4046-1509O. V. Pallah2https://orcid.org/0000-0003-3636-6621I. P. Zayachuk3https://orcid.org/0000-0001-8032-8337N. V. Boyko4https://orcid.org/0000-0002-2467-7513RDE Centre of Molecular Microbiology and Mucosal Immunology, Uzhhorod National University, UkraineRDE Centre of Molecular Microbiology and Mucosal Immunology, Uzhhorod National University, UkraineRDE Centre of Molecular Microbiology and Mucosal Immunology, Uzhhorod National University, UkraineDepartment of Physiology and Pathophysiology, Uzhhorod National University, UkraineRDE Centre of Molecular Microbiology and Mucosal Immunology, Uzhhorod National University, UkraineRecent research on human microbiome provide opportunities to develop functional foods of new generation that can regulate intestinal microbiota and the biochemical status of the individual. The aim of the study was to determine the effect of individually designed nutrition on the intestinal microbiota and metabolic parameters of rats. Outbred laboratory rats with obesity were randomly divided into 9 groups (n = 12) depending on the type of food ingredients taken orally for three months. The ratio of the intestinal commensal microorganisms main groups, as well as the lipid profile and the content of glucose, urea, calcium in the serum of animals were determined. It was shown that cholesterol level in the serum was reduced in experimental groups after consumption of lactobacilli suspension, blueberry juice, fermented milk drink based on lactobacilli, fermented milk drink with blueberry juice, sauerkraut. In most cases, the gut microbiome of experimental animals was characterized by a consistently high level of lacto and other beneficial bacteria and decreased amount of opportunistic microorganisms at the end of the experiment compared with animals in the control group. Based on the obtained data, we first proposed the principles of creating functional products by synergistically combining components of edible plants that act as prebiotics and microorganisms that act as probiotics for personalized use, targeted correction of intestinal microbiome and prevention of noncommunicable diseases.http://ukrbiochemjournal.org/wp-content/uploads/2021/09/Bati_4_21.pdfcholesterolfunctional foodsintestine microbiotalipid profileobesityprebiotic and probiotic components |
| spellingShingle | V. V. Bati T. V. Meleshko O. V. Pallah I. P. Zayachuk N. V. Boyko Personalised diet improve intestine microbiota and metabolism of obese rats The Ukrainian Biochemical Journal cholesterol functional foods intestine microbiota lipid profile obesity prebiotic and probiotic components |
| title | Personalised diet improve intestine microbiota and metabolism of obese rats |
| title_full | Personalised diet improve intestine microbiota and metabolism of obese rats |
| title_fullStr | Personalised diet improve intestine microbiota and metabolism of obese rats |
| title_full_unstemmed | Personalised diet improve intestine microbiota and metabolism of obese rats |
| title_short | Personalised diet improve intestine microbiota and metabolism of obese rats |
| title_sort | personalised diet improve intestine microbiota and metabolism of obese rats |
| topic | cholesterol functional foods intestine microbiota lipid profile obesity prebiotic and probiotic components |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2021/09/Bati_4_21.pdf |
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